{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:51:55Z","timestamp":1790387515566,"version":"4.1.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Liver fibrosis is the static and main (70%\u201080%) component of portal hypertension (PH). We investigated dynamic components of PH by a three\u2010dimensional analysis based on correlation of hepatic collagen proportionate area (CPA) with portal pressure (PP) in animals or HVPG in patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>Different animal models (bile duct ligation: <jats:italic toggle=\"yes\">n<\/jats:italic> = 31, carbon tetrachloride: <jats:italic toggle=\"yes\">n<\/jats:italic> = 12, thioacetamide: <jats:italic toggle=\"yes\">n<\/jats:italic> = 12, choline\u2010deficient high\u2010fat diet: <jats:italic toggle=\"yes\">n<\/jats:italic> = 12) and patients with a confirmed single etiology of cholestatic (primary biliary cholangitis\/primary sclerosing cholangitis: <jats:italic toggle=\"yes\">n<\/jats:italic> = 16), alcohol\u2010associated (<jats:italic toggle=\"yes\">n<\/jats:italic> = 22), and metabolic (NASH: <jats:italic toggle=\"yes\">n<\/jats:italic> = 19) liver disease underwent CPA quantification on liver specimens\/biopsies. Based on CPA\u2010to\u2010PP\/HVPG correlation, potential dynamic components were identified in subgroups of animals\/patients with lower\u2010than\u2010expected and higher\u2010than\u2010expected PP\/HVPG. Dynamic PH components were validated in a patient cohort (<jats:italic toggle=\"yes\">n<\/jats:italic> = 245) using liver stiffness measurement (LSM) instead of CPA. CPA significantly correlated with PP in animal models (Rho = 0.531; <jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.001) and HVPG in patients (Rho = 0.439; <jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.001). Correlation of CPA with PP\/HVPG varied across different animal models and etiologies in patients. In models, severity of hyperdynamic circulation and specific fibrosis pattern (portal fibrosis: <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.02; septa width: <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.03) were associated with PH severity. In patients, hyperdynamic circulation (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.04), vascular dysfunction\/angiogenesis (VWF\u2010Ag: <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.03; soluble vascular endothelial growth factor receptor 1: <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.03), and bile acids (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.04) were dynamic modulators of PH. The LSM\u2010HVPG validation cohort confirmed these and also indicated IL\u20106 (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.008) and hyaluronic acid (HA: <jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.001) as dynamic PH components.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The relative contribution of \u201cstatic\u201d fibrosis on PH severity varies by type of liver injury. Next to hyperdynamic circulation, increased bile acids, VWF\u2010Ag, IL\u20106, and HA seem to indicate a pronounced dynamic component of PH in patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.32220","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T09:11:29Z","timestamp":1635585089000},"page":"610-622","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":48,"title":["Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies"],"prefix":"10.1097","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1279-1148","authenticated-orcid":false,"given":"Philipp","family":"K\u00f6nigshofer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III,Medical University of Vienna,Vienna,Austria"},{"name":"Vienna Experimental Hepatic 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