{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:07:41Z","timestamp":1791461261880,"version":"4.3.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Angiotensin\u2010converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can inhibit liver fibrogenesis in animal models. We aimed to evaluate the impact of ACEI\/ARB use on the risk of liver cancer and cirrhosis complications in patients with NAFLD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>We conducted a retrospective, territory\u2010wide cohort study of adult patients with NAFLD diagnosed between January 2000 and December 2014 to allow for at least 5 years of follow\u2010up. ACEI or ARB users were defined as patients who had received ACEI or ARB treatment for at least 6 months. The primary endpoint was liver\u2010related events (LREs), defined as a composite endpoint of liver cancer and cirrhosis complications. We analyzed data from 12,327 NAFLD patients (mean age, 54.2\u00a0\u00b1\u00a014.7 years; 6163 men [50.0%]); 6805 received ACEIs, and 2877 received ARBs. After propensity score weighting, ACEI treatment was associated with a lower risk of LREs (weighted subdistribution hazard ratio [SHR], 0.48; 95% CI, 0.35\u20130.66; <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0&lt;\u00a00.001), liver cancer (weighted SHR, 0.46; 95% CI, 0.28\u20130.75; <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.002), and cirrhosis complications (weighted SHR, 0.42; 95% CI, 0.27\u20130.66; <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0&lt;\u00a00.001), but ARB was not. In subgroup analysis, ACEI treatment was associated with greater reduction in LREs in patients with chronic kidney diseases (CKDs) than those without (CKD\u2010weighted SHR, 0.74; 95% CI, 0.52\u20130.96; <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.036; non\u2010CKD\u2010weighted SHR, 0.15; 95% CI, 0.07\u20130.33; <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>ACEI, rather than ARB, treatment is associated with a lower risk of LREs in NAFLD patients, especially among those with CKD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.32294","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:38:02Z","timestamp":1640227082000},"page":"469-482","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":81,"title":["Angiotensin\u2010converting enzyme inhibitors prevent liver\u2010related events in nonalcoholic fatty liver disease"],"prefix":"10.1097","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-8904","authenticated-orcid":false,"given":"Xinrong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Lai\u2010Hung","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry Cheuk\u2010Fung","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Kit","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki Wing\u2010Ki","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huapeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy Che\u2010To","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,Prince of Wales Hospital,Shatin,Hong Kong"},{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Institute of Digestive Disease,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Medical Data Analytic Centre (MDAC),The Chinese University of Hong Kong,Shatin,Hong Kong"},{"name":"Union Hospital,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-9410","authenticated-orcid":false,"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department 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