{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:22:53Z","timestamp":1792624973102,"version":"4.5.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Liver regeneration (LR) is vital for the recovery of liver function after hepatectomy. Limited regeneration capacity, together with insufficient remnant liver volume, is a risk factor for posthepatectomy liver failure (PHLF) resulting from small\u2010for\u2010size syndrome. Although inflammation plays an important role in controlling LR, the underlying mechanisms still remain obscure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      We identified C\u2010C motif chemokine ligand (CCL) 5 as an important negative regulator for LR. CCL5 levels were elevated after partial hepatectomy (PHx), both in healthy donors of living donor liver transplantation (LT) and PHx mouse models.\n                      <jats:italic toggle=\"yes\">Ccl5<\/jats:italic>\n                      knockout mice displayed improved survival after 90% PHx and enhanced LR 36 h after 70% PHx. However, primary hepatocytes from\n                      <jats:italic toggle=\"yes\">Ccl5\u2212\/\u2212<\/jats:italic>\n                      mice exposed to growth factors in vitro showed no proliferation advantage compared to those from wild\u2010type (WT) mice. Flow cytometry analysis showed that proportions of Ly6C\n                      <jats:sup>lo<\/jats:sup>\n                      macrophages were significantly increased in\n                      <jats:italic toggle=\"yes\">Ccl5\u2212\/\u2212<\/jats:italic>\n                      mice after 70% PHx. RNA\u2010sequencing analysis revealed that sorted macrophages (CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>lo&amp;hi<\/jats:sup>\n                      ) manifested enhanced expression of reparative genes in\n                      <jats:italic toggle=\"yes\">Ccl5\u2212\/\u2212<\/jats:italic>\n                      mice compared to WT mice. Mechanistically, CCL5 induced macrophages toward proinflammatory Ly6C\n                      <jats:sup>hi<\/jats:sup>\n                      phenotype, thereby inhibiting the production of hepatocyte growth factor (HGF) through the C\u2010C motif chemokine receptor (CCR) 1\u2013 and CCR5\u2010mediated forkhead box O (FoxO) 3a pathways. Finally, blockade of CCL5 greatly optimized survival and boosted LR in the mouse PHx model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that inhibition of CCL5 is a promising strategy to improve regeneration restoration by enhancing HGF secretion from reparative macrophages through the FoxO3a pathway, which may potentially reduce the mortality of PHLF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32458","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T04:15:37Z","timestamp":1647317737000},"page":"1706-1722","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":50,"title":["C\u2010C motif chemokine ligand 5 confines liver regeneration by down\u2010regulating reparative macrophage\u2010derived hepatocyte growth factor in a forkhead box O 3a\u2013dependent manner"],"prefix":"10.1097","volume":"76","author":[{"given":"Miao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Transplantation,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China"},{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Jiao","sequence":"additional","affiliation":[{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Transplantation,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Transplantation,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Transplantation,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Shang","sequence":"additional","affiliation":[{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Qian","sequence":"additional","affiliation":[{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Wu","sequence":"additional","affiliation":[{"name":"191610,Shanghai Key Laboratory of Molecular Imaging,Shanghai University of Medicine and Health Sciences,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1406-051X","authenticated-orcid":false,"given":"Xiaoni","family":"Kong","sequence":"additional","affiliation":[{"name":"Central Laboratory,Department of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Transplantation,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"hep32458-bib-0001-20250415","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jamaoncol.2019.2996","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability\u2010adjusted life\u2010years for 29 cancer groups, 1990 to 2017","volume":"5","year":"2019","journal-title":"JAMA Oncol"},{"key":"hep32458-bib-0002-20250415","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41575-020-0314-8","article-title":"Modern therapeutic approaches for the treatment of malignant liver tumours","volume":"17","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep32458-bib-0003-20250415","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.amjsurg.2019.05.007","article-title":"Outcomes of extended hepatectomy for hepatobiliary tumors. Initial experience from a non\u2010university hepatobiliary center","volume":"219","year":"2020","journal-title":"Am J Surg"},{"key":"hep32458-bib-0004-20250415","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jamcollsurg.2015.11.007","article-title":"Management of postoperative hepatic failure","volume":"222","year":"2016","journal-title":"J Am Coll Surg"},{"key":"hep32458-bib-0005-20250415","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jhep.2017.10.024","article-title":"Should living donor liver transplantation be an option when deceased donation is not?","volume":"68","year":"2018","journal-title":"J Hepatol"},{"key":"hep32458-bib-0006-20250415","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jhep.2012.04.015","article-title":"Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"hep32458-bib-0007-20250415","doi-asserted-by":"crossref","first-page":"401","DOI":"10.12659\/AOT.916038","article-title":"Effect of portal venous pressure on liver function of donors in living donor liver transplantation","volume":"24","year":"2019","journal-title":"Ann Transplant"},{"key":"hep32458-bib-0008-20250415","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1053\/j.gastro.2008.04.018","article-title":"Donor morbidity after living donation for liver transplantation","volume":"135","year":"2008","journal-title":"Gastroenterology"},{"key":"hep32458-bib-0009-20250415","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep32458-bib-0010-20250415","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.118.314569","article-title":"Interleukin\u201035 promotes macrophage survival and improves wound healing after myocardial infarction in mice","volume":"124","year":"2019","journal-title":"Circ Res"},{"key":"hep32458-bib-0011-20250415","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep32458-bib-0012-20250415","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev-physiol-022516-034356","article-title":"Mechanisms of organ injury and repair by macrophages","volume":"79","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"hep32458-bib-0013-20250415","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41419-021-03616-9","article-title":"Ceramides and sphingosine\u20101\u2010phosphate mediate the distinct effects of M1\/M2\u2010macrophage infusion on liver recovery after hepatectomy","volume":"12","year":"2021","journal-title":"Cell Death Dis"},{"key":"hep32458-bib-0014-20250415","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","year":"2016","journal-title":"Immunity"},{"key":"hep32458-bib-0015-20250415","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jcmgh.2018.12.009","article-title":"Deletion of C\u2010C Motif chemokine ligand 5 worsens invariant natural killer T\u2010cell\u2010mediated hepatitis via compensatory up\u2010regulation of CXCR2\u2010related chemokine activity","volume":"7","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"hep32458-bib-0016-20250415","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2016.12.011","article-title":"Functional role of CCL5\/RANTES for HCC progression during chronic liver disease","volume":"66","year":"2017","journal-title":"J Hepatol"},{"key":"hep32458-bib-0017-20250415","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1517\/14728222.2013.837886","article-title":"Targeting CCL5 in inflammation","volume":"17","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"hep32458-bib-0018-20250415","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41423-019-0279-0","article-title":"CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization","volume":"17","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"hep32458-bib-0019-20250415","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective hepatocyte regeneration in interleukin\u20106\u2010deficient mice","volume":"274","year":"1996","journal-title":"Science"},{"key":"hep32458-bib-0020-20250415","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/hep.30919","article-title":"CREBZF as a key regulator of STAT3 pathway in the control of liver regeneration in mICE","volume":"71","year":"2020","journal-title":"Hepatology"},{"key":"hep32458-bib-0021-20250415","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1136\/gutjnl-2017-314061","article-title":"Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma","volume":"67","year":"2018","journal-title":"Gut"},{"key":"hep32458-bib-0022-20250415","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: liver regeneration and normal liver tissue maintenance","volume":"65","year":"2017","journal-title":"Hepatology"},{"key":"hep32458-bib-0023-20250415","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep4.1597","article-title":"MicroRNA\u2010125b\u20105p regulates hepatocyte proliferation during the termination phase of liver regeneration","volume":"4","year":"2020","journal-title":"Hepatol Commun"},{"key":"hep32458-bib-0024-20250415","doi-asserted-by":"crossref","first-page":"893","DOI":"10.7150\/ijbs.39725","article-title":"Mesenchymal stromal cells promote liver regeneration through regulation of immune cells","volume":"16","year":"2020","journal-title":"Int J Biol Sci"},{"key":"hep32458-bib-0025-20250415","article-title":"Understanding the marvels behind liver regeneration","volume":"8","year":"2019","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"Suppl. 4","key":"hep32458-bib-0026-20250415","first-page":"iv6","article-title":"Regulation of liver regeneration","volume":"19","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"hep32458-bib-0027-20250415","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/17474124.2020.1815532","article-title":"The vascular endothelial growth factor signaling pathway regulates liver sinusoidal endothelial cells during liver regeneration after partial hepatectomy","volume":"15","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"hep32458-bib-0028-20250415","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2018.02.009","article-title":"Inhibition of microsomal prostaglandin E synthase\u20101 facilitates liver repair after hepatic injury in mice","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"hep32458-bib-0029-20250415","article-title":"Modulation of liver regeneration via myeloid PTEN deficiency","volume":"8","year":"2017","journal-title":"Cell Death Dis"},{"key":"hep32458-bib-0030-20250415","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1158\/1078-0432.CCR-18-3421","article-title":"Breast phyllodes tumors recruit and repolarize tumor\u2010associated macrophages via secreting CCL5 to promote malignant progression, which can be inhibited by CCR5 inhibition therapy","volume":"25","year":"2019","journal-title":"Clin Cancer Res"},{"key":"hep32458-bib-0031-20250415","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/hep.28682","article-title":"Chemokine (C\u2010C motif) receptor 2\u2010positive monocytes aggravate the early phase of acetaminophen\u2010induced acute liver injury","volume":"64","year":"2016","journal-title":"Hepatology"},{"key":"hep32458-bib-0032-20250415","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","article-title":"CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis","volume":"76","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"hep32458-bib-0033-20250415","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/s41467-019-09402-8","article-title":"Mechanical stretch induces hair regeneration through the alternative activation of macrophages","volume":"10","year":"2019","journal-title":"Nat Commun"},{"key":"hep32458-bib-0034-20250415","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41416-019-0482-x","article-title":"M2 macrophages mediate sorafenib resistance by secreting HGF in a feed\u2010forward manner in hepatocellular carcinoma","volume":"121","year":"2019","journal-title":"Br J Cancer"},{"key":"hep32458-bib-0035-20250415","doi-asserted-by":"crossref","first-page":"103503","DOI":"10.1016\/j.dci.2019.103503","article-title":"Function of CCL5 in maternal\u2010fetal interface of pig during early pregnancy","volume":"103","year":"2020","journal-title":"Dev Comp Immunol"},{"key":"hep32458-bib-0036-20250415","first-page":"506","article-title":"Constitutive and stress\u2010induced expression of CCL5 machinery in rodent retina","volume":"8","year":"2017","journal-title":"J Clin Cell Immunol"},{"key":"hep32458-bib-0037-20250415","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1172\/JCI41732","article-title":"Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice","volume":"120","year":"2010","journal-title":"J Clin Invest"},{"key":"hep32458-bib-0038-20250415","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-020-0088-2","article-title":"Therapeutic strategies targeting FOXO transcription factors","volume":"20","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"hep32458-bib-0039-20250415","doi-asserted-by":"crossref","first-page":"12748","DOI":"10.1038\/ncomms12748","article-title":"Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium","volume":"7","year":"2016","journal-title":"Nat Commun"},{"key":"hep32458-bib-0040-20250415","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.4049\/jimmunol.1601503","article-title":"AKT2 regulates pulmonary inflammation and fibrosis via modulating macrophage activation","volume":"198","year":"2017","journal-title":"J Immunol"},{"key":"hep32458-bib-0041-20250415","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/jcmm.16238","article-title":"Formononetin ameliorates muscle atrophy by regulating myostatin\u2010mediated PI3K\/Akt\/FoxO3a pathway and satellite cell function in chronic kidney disease","volume":"25","year":"2021","journal-title":"J Cell Mol Med"},{"key":"hep32458-bib-0042-20250415","article-title":"Kcnh2 mediates FAK\/AKT\u2010FOXO3A pathway to attenuate sepsis\u2010induced cardiac dysfunction","volume":"54","year":"2021","journal-title":"Cell Prolif"},{"key":"hep32458-bib-0043-20250415","first-page":"20862","article-title":"TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K\/AKT\/FoxO3a signaling pathway in Alzheimer's disease mice","volume":"12","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"hep32458-bib-0044-20250415","doi-asserted-by":"crossref","first-page":"110141","DOI":"10.1016\/j.cellsig.2021.110141","article-title":"Interleukin\u201018 accelerates cardiac inflammation and dysfunction during ischemia\/reperfusion injury by transcriptional activation of CXCL16","volume":"87","year":"2021","journal-title":"Cell Signal"},{"key":"hep32458-bib-0045-20250415","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.3389\/fimmu.2019.02922","article-title":"FOXO3 transcription factor regulates IL\u201010 expression in mycobacteria\u2010infected macrophages, tuning their polarization and the subsequent adaptive immune response","volume":"10","year":"2019","journal-title":"Front Immunol"},{"key":"hep32458-bib-0046-20250415","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41419-020-03142-0","article-title":"Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A\u2010VEGF signaling","volume":"11","year":"2020","journal-title":"Cell Death Dis"},{"key":"hep32458-bib-0047-20250415","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s41419-018-0943-9","article-title":"Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF\u2010kappaB directly regulates PUMA\u2010dependent apoptosis","volume":"9","year":"2018","journal-title":"Cell Death Dis"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.32458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.32458","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T12:46:38Z","timestamp":1744721198000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.32458","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741899362.793597013","asserted-by":"object"}]},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"2022-01-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}