{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:38:57Z","timestamp":1792132737502,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>The association between birth weight (BW) and metabolic outcomes has been described since the 1980s but NAFLD has been rarely studied. This study aimed to investigate the association between BW and NAFLD occurrence in adult subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>The study population consisted of participants from the French nationwide Constances cohort from 2012 to 2019. Participants with a history of chronic viral hepatitis or excessive alcohol consumption were excluded. Noninvasive diagnosis of NAFLD and fibrosis was performed using a combination of the Fatty Liver Index (FLI) and the Forns Index. The relationship between BW and NAFLD was analyzed with a sex\u2010stratified logistic regression model adjusted for sociodemographic parameters, lifestyle, and birth term, whereas liver fibrosis was analyzed with a sex\u2010stratified linear regression model. In total, 55,034 individuals with reliable BW were included (43% men, mean age: 38 years). NAFLD (FLI\u00a0\u2265\u00a060) was present in 5530 individuals (10%). Multivariate logistic regression showed a significant U\u2010shaped relationship between BW and NAFLD, with no significant interaction with sex. A significant and slightly decreasing association was found between BW and Forns Index (<jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.05; <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0=\u00a00.04). Premature birth (OR, 1.23; 95% CI, 1.03\u20131.48 for birth between 33 and 37 weeks versus\u00a0\u2265\u00a037 weeks) was associated with NAFLD, with a significant direct effect of premature birth, and without an indirect effect of low BW in mediation analysis. Forns Index was not significantly higher in participants with preterm birth compared to full\u2010term birth.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This large prospective adult\u2010based cohort confirms the relationship between BW and NAFLD occurrence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.32540","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T05:09:33Z","timestamp":1651036173000},"page":"1438-1451","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":44,"title":["Association between birth weight, preterm birth, and nonalcoholic fatty liver disease in a community\u2010based cohort"],"prefix":"10.1097","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-7592","authenticated-orcid":false,"given":"Coralie","family":"Amadou","sequence":"first","affiliation":[{"name":"Paris\u2010Saclay University,Paris,France"},{"name":"Department of Diabetes and Endocrinology,Sud\u2010Francilien Hospital,Corbeil\u2010Essonnes,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumarou","family":"Nabi","sequence":"additional","affiliation":[{"name":"Inserm Unit\u00e9 Mixte de Recherche\u2010S1136,Institut Pierre\u2010Louis Epid\u00e9miologie et Sant\u00e9 Publique,Sorbonne Universit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-5579","authenticated-orcid":false,"given":"Lawrence","family":"Serfaty","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Department,H\u00f4pital Hautepierre,H\u00f4pitaux Universitaires de Strasbourg,Strasbourg,France"},{"name":"Inserm Unit\u00e9 Mixte de Recherche_S938,Sorbonne Universit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8772-9029","authenticated-orcid":false,"given":"Karine","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Inserm Unit\u00e9 Mixte de Recherche\u2010S1136,Institut Pierre\u2010Louis Epid\u00e9miologie et Sant\u00e9 Publique,Sorbonne Universit\u00e9,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Boursier","sequence":"additional","affiliation":[{"name":"H\u00e9modynamique, Interaction Fibrose et Invasivit\u00e9 Tumorales H\u00e9patiques Laboratory,Unit\u00e9 Propre de Recherche de l'Enseignement Sup\u00e9rieur EA3859,Structure F\u00e9d\u00e9rative de Recherche 4208,Angers University,Angers,France"},{"name":"Hepato\u2010Gastroenterology Department,Angers University Hospital,Angers,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[{"name":"Hepato\u2010Gastroenterology,Centre hospitalier universitaire Lille,Lille,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Ribet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 011,Population\u2010Based Epidemiological Cohorts,Inserm,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"de Ledinghen","sequence":"additional","affiliation":[{"name":"Hepatology Unit,Haut\u2010L\u00e9v\u00eaque Hospital,Bordeaux University Hospital,Pessac,France"},{"name":"Inserm U1053,Bordeaux University,Bordeaux,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Zins","sequence":"additional","affiliation":[{"name":"Paris\u2010Saclay University,Paris,France"},{"name":"Unit\u00e9 Mixte de Recherche 011,Population\u2010Based Epidemiological Cohorts,Inserm,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Aline","family":"Charles","sequence":"additional","affiliation":[{"name":"Centre for Research in Epidemiology and Statistics,Inserm,Institut National de Recherche Pour l'agriculture, l'alimentation et l'environnement,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"issue":"8663","key":"hep32540-bib-0001-20241017","first-page":"577","article-title":"Weight in infancy and death from ischaemic heart disease","volume":"2","year":"1989","journal-title":"Lancet"},{"issue":"6809","key":"hep32540-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/bmj.303.6809.1019","article-title":"Fetal and infant growth and impaired glucose tolerance at age 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