{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:57:31Z","timestamp":1793116651703,"version":"4.5.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>\n                      Intestinal farnesoid X receptor (FXR) plays a critical role in alcohol\u2010associated liver disease (ALD). We aimed to investigate whether alcohol\u2010induced dysbiosis increased intestinal microRNA194 (miR194) that suppressed\n                      <jats:italic toggle=\"yes\">Fxr<\/jats:italic>\n                      transcription and whether\n                      <jats:italic toggle=\"yes\">Lactobacillus rhamnosus<\/jats:italic>\n                      GG\u2013derived exosome\u2010like nanoparticles (LDNPs) protected against ALD through regulation of intestinal miR194\u2010FXR signaling in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      Binge\u2010on\u2010chronic alcohol exposure mouse model was utilized. In addition to the decreased ligand\u2010mediated FXR activation, alcohol feeding repressed intestinal\n                      <jats:italic toggle=\"yes\">Fxr<\/jats:italic>\n                      transcription and increased miR194 expression. This transcriptional suppression of\n                      <jats:italic toggle=\"yes\">Fxr<\/jats:italic>\n                      by miR194 was confirmed in intestinal epithelial Caco\u20102 cells and mouse enteriods. The alcohol feeding\u2013reduced intestinal FXR activation was further demonstrated by the reduced FXR reporter activity in fecal samples and by the decreased fibroblast growth factor 15 (Fgf15) messenger RNA (mRNA) in intestine and protein levels in the serum, which caused an increased hepatic bile acid synthesis and lipogeneses. We further demonstrated that alcohol feeding increased\u2010miR194 expression was mediated by taurine\u2010upregulated gene 1 (Tug1) through gut microbiota regulation of taurine metabolism. Importantly, 3\u2010day oral administration of LDNPs increased bile salt hydrolase (BSH)\u2010harboring bacteria that decreased conjugated bile acids and increased gut taurine concentration, which upregulated Tug1, leading to a suppression of intestinal miR194 expression and recovery of FXR activation. Activated FXR upregulated FGF15 signaling and subsequently reduced hepatic bile acid synthesis and lipogenesis and attenuated ALD. These protective effects of LDNPs were eliminated in intestinal\n                      <jats:italic toggle=\"yes\">Fxr<\/jats:italic>\n                      <jats:sup>\u0394IEC<\/jats:sup>\n                      and\n                      <jats:italic toggle=\"yes\">Fgf15<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice. We further showed that miR194 was upregulated, whereas BSH activity and taurine levels were decreased in fecal samples of patients with ALD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results demonstrated that gut microbiota\u2013mediated miR194 regulation contributes to ALD pathogenesis and to the protective effects of LDNPs through modulating intestinal FXR signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32608","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T09:14:46Z","timestamp":1654938886000},"page":"1164-1180","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":58,"title":["Probiotic\u2010derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation"],"prefix":"10.1097","volume":"77","author":[{"given":"Mengwei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"He","sequence":"additional","affiliation":[{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Department of Chemistry, University of Louisville, Louisville, Kentucky, USA"},{"name":"Hepatobiology & Toxicology Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsalya","family":"Vatsalya","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang\u2010Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Robley Rex VA Medical Center, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-6313","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Department of Chemistry, University of Louisville, Louisville, Kentucky, USA"},{"name":"Hepatobiology & Toxicology Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish","family":"Barve","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Hepatobiology & Toxicology Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Hepatobiology & Toxicology Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Robley Rex VA Medical Center, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Louisville, Louisville, Kentucky, USA"},{"name":"Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA"},{"name":"Alcohol Research Center, University of Louisville, Louisville, Kentucky, USA"},{"name":"Hepatobiology & Toxicology Center, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"hep32608-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1089-3261(05)70086-6","article-title":"Cholestasis and alcoholic liver disease","volume":"3","year":"1999","journal-title":"Clin Liver Dis"},{"key":"hep32608-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile\u2010acid signalling for metabolic diseases","volume":"7","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"hep32608-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.dld.2018.12.026","article-title":"FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury","volume":"51","year":"2019","journal-title":"Dig Liver Dis"},{"key":"hep32608-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.dld.2018.04.009","article-title":"FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice","volume":"50","year":"2018","journal-title":"Dig Liver Dis"},{"key":"hep32608-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/hep.29676","article-title":"Modulation of the intestinal bile acid\/farnesoid X receptor\/fibroblast growth factor 15 axis improves alcoholic liver disease in mice","volume":"67","year":"2018","journal-title":"Hepatology"},{"key":"hep32608-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/hep4.1256","article-title":"FXR and TGR5 agonists ameliorate liver injury, steatosis, and inflammation after binge or prolonged alcohol feeding in mice","volume":"2","year":"2018","journal-title":"Hepatol Commun"},{"key":"hep32608-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1016\/j.bbadis.2017.09.020","article-title":"MicroRNA\u2010194 inhibition improves dietary\u2010induced non\u2010alcoholic fatty liver disease in mice through targeting on FXR","volume":"1863","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"hep32608-bib-0008-20250824","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.ajpath.2011.08.039","article-title":"Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia\u2010inducible factor, promotes intestinal integrity and ameliorates alcohol\u2010induced liver injury","volume":"179","year":"2011","journal-title":"Am J Pathol"},{"key":"hep32608-bib-0009-20250824","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.alcohol.2008.08.006","article-title":"Probiotics restore bowel flora and improve liver enzymes in human alcohol\u2010induced liver injury: a pilot study","volume":"42","year":"2008","journal-title":"Alcohol"},{"key":"hep32608-bib-0010-20250824","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/hep.30975","article-title":"Probiotic Lactobacillus rhamnosus GG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice","volume":"71","year":"2020","journal-title":"Hepatology"},{"key":"hep32608-bib-0011-20250824","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep4.1679","article-title":"Exosome\u2010like nanoparticles from Lactobacillus rhamnosus GG protect against alcohol\u2010associated liver disease through intestinal aryl hydrocarbon receptor in mice","volume":"5","year":"2021","journal-title":"Hepatol Commun"},{"key":"hep32608-bib-0012-20250824","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41374-020-0439-y","article-title":"Enhanced alcoholic liver disease in mice with intestine\u2010specific farnesoid X receptor deficiency","volume":"100","year":"2020","journal-title":"Lab Invest"},{"key":"hep32608-bib-0013-20250824","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/toxsci\/kfr177","article-title":"Dose\u2013response of five bile acids on serum and liver bile acid concentrations and hepatotoxicty in mice","volume":"123","year":"2011","journal-title":"Toxicol Sci"},{"key":"hep32608-bib-0014-20250824","article-title":"12\u03b1\u2010Hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats","volume":"1865","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"hep32608-bib-0015-20250824","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","year":"2005","journal-title":"Cell Metab"},{"key":"hep32608-bib-0016-20250824","article-title":"Intestinal FGF15\/19 physiologically repress hepatic lipogenesis in the late fed\u2010state by activating SHP and DNMT3A","volume":"11","year":"2020","journal-title":"Nat Commun"},{"key":"hep32608-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gad.1773909","article-title":"Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin\u2010proteasomal degradation","volume":"23","year":"2009","journal-title":"Genes Dev"},{"key":"hep32608-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1074\/jbc.M808747200","article-title":"FGF15\/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action","volume":"284","year":"2009","journal-title":"J Biol Chem"},{"key":"hep32608-bib-0019-20250824","article-title":"Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis","volume":"13","year":"2015","journal-title":"J Transl Med"},{"key":"hep32608-bib-0020-20250824","article-title":"Discrimination of the expression of paralogous microRNA precursors that share the same major mature form","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"hep32608-bib-0021-20250824","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chom.2015.12.005","article-title":"The host shapes the gut microbiota via fecal MicroRNA","volume":"19","year":"2016","journal-title":"Cell Host Microbe"},{"key":"hep32608-bib-0022-20250824","article-title":"Fecal microRNAs as potential biomarkers for screening and diagnosis of intestinal diseases","volume":"7","year":"2020","journal-title":"Front Mol Biosci"},{"key":"hep32608-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt\u2010villus structures in vitro without a mesenchymal niche","volume":"459","year":"2009","journal-title":"Nature"},{"key":"hep32608-bib-0024-20250824","article-title":"Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1\/miR\u2010194\/SIRT1 signaling pathway","volume":"18","year":"2021","journal-title":"J Inflamm (Lond)"},{"key":"hep32608-bib-0025-20250824","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.omtn.2019.02.017","article-title":"lncRNA TUG1 promotes cisplatin resistance by regulating CCND2 via epigenetically silencing miR\u2010194\u20105p in bladder cancer","volume":"16","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"hep32608-bib-0026-20250824","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1021\/acs.jproteome.9b00181","article-title":"Profiling of polar metabolites in mouse feces using four analytical platforms to study the effects of cathelicidin\u2010related antimicrobial peptide in alcoholic liver disease","volume":"18","year":"2019","journal-title":"J Proteome Res"},{"key":"hep32608-bib-0027-20250824","article-title":"Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice","volume":"9","year":"2018","journal-title":"Nat Commun"},{"key":"hep32608-bib-0028-20250824","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","article-title":"Recovery of ethanol\u2010induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease","volume":"67","year":"2018","journal-title":"Gut"},{"key":"hep32608-bib-0029-20250824","article-title":"Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome","volume":"7","year":"2019","journal-title":"Microbiome"},{"key":"hep32608-bib-0030-20250824","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","year":"2009","journal-title":"J Lipid Res"},{"key":"hep32608-bib-0031-20250824","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells","volume":"581","year":"2020","journal-title":"Nature"},{"key":"hep32608-bib-0032-20250824","article-title":"Polyphenol\u2010induced improvements in glucose metabolism are associated with bile acid signaling to intestinal farnesoid X receptor","volume":"8","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"hep32608-bib-0033-20250824","article-title":"Theabrownin from Pu\u2010erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism","volume":"10","year":"2019","journal-title":"Nat Commun"},{"key":"hep32608-bib-0034-20250824","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.22771","article-title":"High expression of the bile salt\u2010homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"hep32608-bib-0035-20250824","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/labinvest.2010.107","article-title":"Intestinal FXR\u2010mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice","volume":"90","year":"2010","journal-title":"Lab Invest"},{"key":"hep32608-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/apt.14949","article-title":"Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis","volume":"48","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"hep32608-bib-0037-20250824","article-title":"Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"hep32608-bib-0038-20250824","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jhep.2018.03.031","article-title":"Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"hep32608-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/acer.14619","article-title":"Gut\u2010restricted apical sodium\u2010dependent bile acid transporter inhibitor attenuates alcohol\u2010induced liver steatosis and injury in mice","volume":"45","year":"2021","journal-title":"Alcohol Clin Exp Res"},{"key":"hep32608-bib-0040-20250824","doi-asserted-by":"crossref","first-page":"G929","DOI":"10.1152\/ajpgi.00315.2013","article-title":"Colonic inflammation and secondary bile acids in alcoholic cirrhosis","volume":"306","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep32608-bib-0041-20250824","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hep4.1885","article-title":"Development of alcohol\u2010associated hepatitis is associated with specific changes in gut\u2010modified bile acids","volume":"6","year":"2022","journal-title":"Hepatol Commun"},{"key":"hep32608-bib-0042-20250824","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/hep.22811","article-title":"Taurine supplementation prevents ethanol\u2010induced decrease in serum adiponectin and reduces hepatic steatosis in rats","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"hep32608-bib-0043-20250824","doi-asserted-by":"crossref","first-page":"G32","DOI":"10.1152\/ajpgi.00024.2012","article-title":"Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol\u2010induced intestinal permeability and liver injury","volume":"303","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.32608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.32608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:09:23Z","timestamp":1756073363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.32608","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"assertion":[{"value":"2022-01-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}