{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:45:22Z","timestamp":1787748322556,"version":"build-2784847793"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/ http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD, in line with highly prevalent dyslipidemia in this population. Increased plasma triglyceride (TG)\u2010rich lipoprotein (TRL) concentrations, an important risk factor for CVD, are closely linked with hepatic TG content. Therefore, it is of great interest to identify regulatory mechanisms of hepatic TRL production and remnant uptake in the setting of hepatic steatosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      To identify liver\u2010regulated pathways linking intrahepatic and plasma TG metabolism, we performed transcriptomic analysis of liver biopsies from two independent cohorts of obese patients. Hepatic encoding apolipoprotein F (\n                      <jats:italic toggle=\"yes\">APOF<\/jats:italic>\n                      ) expression showed the fourth\u2010strongest negatively correlation with hepatic steatosis and the strongest negative correlation with plasma TG levels. The effects of adenoviral\u2010mediated human ApoF (hApoF) overexpression on plasma and hepatic TG were assessed in C57BL6\/J mice. Surprisingly, hApoF overexpression increased both hepatic very low density lipoprotein (VLDL)\u2010TG secretion and hepatic lipoprotein remnant clearance, associated a\u2009~25% reduction in plasma TG levels. Conversely, reducing endogenous ApoF expression reduced VLDL secretion\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      , and reduced hepatocyte VLDL uptake by ~15%\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      . Transcriptomic analysis of\n                      <jats:italic toggle=\"yes\">APOF<\/jats:italic>\n                      \u2010overexpressing mouse livers revealed a gene signature related to enhanced ApoB\u2010lipoprotein clearance, including increased expression of\n                      <jats:italic toggle=\"yes\">Ldlr<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Lrp1<\/jats:italic>\n                      , among others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These data reveal a previously undescribed role for ApoF in the control of plasma and hepatic lipoprotein metabolism by favoring VLDL\u2010TG secretion and hepatic lipoprotein remnant particle clearance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32631","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T08:54:45Z","timestamp":1655974485000},"page":"1287-1302","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride\u2010rich lipoprotein metabolism"],"prefix":"10.1097","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-8452","authenticated-orcid":false,"given":"Audrey","family":"Deprince","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-7258","authenticated-orcid":false,"given":"Nathalie","family":"Hennuyer","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-5571","authenticated-orcid":false,"given":"Sander","family":"Kooijman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C. M.","family":"Pronk","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-8667","authenticated-orcid":false,"given":"Eric","family":"Baug\u00e9","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Lienard","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Verrijken","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Antwerp, Belgium"},{"name":"Laboratory of Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Dirinck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Antwerp, Belgium"},{"name":"Laboratory of Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-9259","authenticated-orcid":false,"given":"Luisa","family":"Vonghia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"Laboratory of Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-9023","authenticated-orcid":false,"given":"Elo\u00efse","family":"Woitrain","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels J.","family":"Kloosterhuis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9onore","family":"Marez","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Jacquemain","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0066-3720","authenticated-orcid":false,"given":"Justina C.","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-1892","authenticated-orcid":false,"given":"Fanny","family":"Lalloyer","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-6146","authenticated-orcid":false,"given":"Delphine","family":"Eberl\u00e9","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-3906","authenticated-orcid":false,"given":"Sandrine","family":"Quemener","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Vallez","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-2627","authenticated-orcid":false,"given":"Anne","family":"Tailleux","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-800X","authenticated-orcid":false,"given":"Mostafa","family":"Kouach","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille, ULR 7365\u2010GRITA\u2010Groupe de Recherche sur les formes Injectables et les Technologies Associ\u00e9es, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Francois","family":"Goossens","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille, ULR 7365\u2010GRITA\u2010Groupe de Recherche sur les formes Injectables et les Technologies Associ\u00e9es, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-2028","authenticated-orcid":false,"given":"Violeta","family":"Raverdy","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1190 \u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Derudas","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Albert","family":"Kuivenhoven","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5449-5817","authenticated-orcid":false,"given":"Mika\u00ebl","family":"Croyal","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France"},{"name":"Universit\u00e9 de Nantes, CHU Nantes, Inserm, CNRS, SFR Sant\u00e9, Inserm UMS 016, CNRS UMS 3556, Nantes, France"},{"name":"CRNH\u2010Ouest Mass Spectrometry Core Facility, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3039-4365","authenticated-orcid":false,"given":"Bart","family":"van de Sluis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7527-4714","authenticated-orcid":false,"given":"Sven","family":"Francque","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium"},{"name":"Laboratory of Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-3766","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Pattou","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1190 \u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-4988","authenticated-orcid":false,"given":"Patrick C. N.","family":"Rensen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-1503","authenticated-orcid":false,"given":"Bart","family":"Staels","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0028-5988","authenticated-orcid":false,"given":"Joel T.","family":"Haas","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010 EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"hep32631-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD","volume":"72","year":"2020","journal-title":"Hepatology"},{"key":"hep32631-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1093\/eurheartj\/ehab551","article-title":"Triglyceride\u2010rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies\u2014a consensus statement from the European Atherosclerosis Society","volume":"42","year":"2021","journal-title":"Euro Heart J"},{"key":"hep32631-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/ATVBAHA.107.160192","article-title":"Overproduction of very low\u2010density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome","volume":"28","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep32631-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1053\/j.gastro.2007.11.038","article-title":"Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"hep32631-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","year":"2005","journal-title":"J Clin Invest"},{"key":"hep32631-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"hep32631-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI134165","article-title":"Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease","volume":"130","year":"2020","journal-title":"J Clin Invest"},{"key":"hep32631-bib-0008-20250824","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1210\/jc.2016-1500","article-title":"VLDL triglyceride kinetics in lean, overweight, and obese men and women","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"hep32631-bib-0009-20250824","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1161\/01.ATV.0000172689.53992.25","article-title":"Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia","volume":"25","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep32631-bib-0010-20250824","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","year":"2008","journal-title":"Nat Genet"},{"key":"hep32631-bib-0011-20250824","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome\u2010wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","year":"2014","journal-title":"Nat Genet"},{"key":"hep32631-bib-0012-20250824","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bbalip.2014.03.013","article-title":"Physiological regulation of lipoprotein lipase","volume":"1841","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"hep32631-bib-0013-20250824","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1161\/ATVBAHA.111.224808","article-title":"Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects","volume":"31","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep32631-bib-0014-20250824","article-title":"Dysregulated lipid metabolism links NAFLD to cardiovascular disease","volume":"42","year":"2020","journal-title":"Mol Metab"},{"key":"hep32631-bib-0015-20250824","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1194\/jlr.P023176","article-title":"Low density lipoprotein delays clearance of triglyceride\u2010rich lipoprotein by human subcutaneous adipose tissue","volume":"54","year":"2013","journal-title":"J Lipid Res"},{"key":"hep32631-bib-0016-20250824","article-title":"The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"hep32631-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1021\/bi00599a014","article-title":"Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma","volume":"17","year":"1978","journal-title":"Biochemistry"},{"key":"hep32631-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/ATVBAHA.108.177105","article-title":"Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo","volume":"29","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep32631-bib-0019-20250824","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0022-2275(20)39178-1","article-title":"Regulation of lipid transfer between lipoproteins by an endogenous plasma protein: selective inhibition among lipoprotein classes","volume":"35","year":"1994","journal-title":"J Lipid Res"},{"key":"hep32631-bib-0020-20250824","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1194\/jlr.RA119000171","article-title":"ApoF knockdown increases cholesteryl ester transfer to LDL and impairs cholesterol clearance in fat\u2010fed hamsters","volume":"60","year":"2019","journal-title":"J Lipid Res"},{"key":"hep32631-bib-0021-20250824","article-title":"Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients","volume":"12","year":"2019","journal-title":"BMC Med Genomics"},{"key":"hep32631-bib-0022-20250824","article-title":"Interspecies NASH disease activity whole\u2010genome profiling identifies a fibrogenic role of PPARalpha\u2010regulated dermatopontin","volume":"2","year":"2017","journal-title":"JCI Insight"},{"key":"hep32631-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s42255-019-0076-1","article-title":"Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution","volume":"1","year":"2019","journal-title":"Nat Metab"},{"key":"hep32631-bib-0024-20250824","article-title":"Genetic variation in SULF2 is associated with postprandial clearance of triglyceride\u2010rich remnant particles and triglyceride levels in healthy subjects","volume":"8","year":"2013","journal-title":"PLoS One."},{"key":"hep32631-bib-0025-20250824","article-title":"FABP4 and MMP9 levels identified as predictive factors for poor prognosis in patients with nonalcoholic fatty liver using data mining approaches and gene expression analysis","volume":"9","year":"2019","journal-title":"Sci Rep"},{"key":"hep32631-bib-0026-20250824","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jhep.2013.11.007","article-title":"Perilipin discerns chronic from acute hepatocellular steatosis","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep32631-bib-0027-20250824","doi-asserted-by":"crossref","first-page":"11805","DOI":"10.1074\/jbc.RA119.008708","article-title":"Enhanced acetylation of ATP\u2010citrate lyase promotes the progression of nonalcoholic fatty liver disease","volume":"294","year":"2019","journal-title":"J Biol Chem"},{"key":"hep32631-bib-0028-20250824","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jacc.2009.07.056","article-title":"Are you targeting non\u2013high\u2010density lipoprotein cholesterol?","volume":"55","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"hep32631-bib-0029-20250824","article-title":"Kinetic studies to elucidate impaired metabolism of triglyceride\u2010rich lipoproteins in humans","volume":"6","year":"2015","journal-title":"Front Physiol"},{"key":"hep32631-bib-0030-20250824","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1101\/gad.209296.112","article-title":"Biochemistry and pathophysiology of intravascular and intracellular lipolysis","volume":"27","year":"2013","journal-title":"Genes Dev"},{"key":"hep32631-bib-0031-20250824","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/CIRCRESAHA.111.300367","article-title":"Antisense oligonucleotide inhibition of apolipoprotein C\u2010III reduces plasma triglycerides in rodents, nonhuman primates, and humans","volume":"112","year":"2013","journal-title":"Circ Res"},{"key":"hep32631-bib-0032-20250824","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-2275(20)33334-4","article-title":"Remnant lipoprotein metabolism: key pathways involving cell\u2010surface heparan sulfate proteoglycans and apolipoprotein E","volume":"40","year":"1999","journal-title":"J Lipid Res"},{"key":"hep32631-bib-0033-20250824","article-title":"Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development","volume":"6","year":"2015","journal-title":"Nat Commun"},{"key":"hep32631-bib-0034-20250824","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1172\/JCI2673","article-title":"Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2","volume":"102","year":"1998","journal-title":"J Clin Invest"},{"key":"hep32631-bib-0035-20250824","first-page":"200","article-title":"A comparative microscopic and biochemical study of the uptake of fluorescent and 125I\u2010labeled lipoproteins by skin fibroblasts, smooth muscle cells, and peritoneal macrophages in culture","volume":"121","year":"1985","journal-title":"Am J Pathol"},{"key":"hep32631-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cca.2019.09.022","article-title":"Cholesterol in LDL receptor recycling and degradation","volume":"500","year":"2020","journal-title":"Clin Chim Acta"},{"key":"hep32631-bib-0037-20250824","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1073\/pnas.162488899","article-title":"Insig\u20102, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element\u2010binding proteins","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci"},{"key":"hep32631-bib-0038-20250824","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.atherosclerosis.2013.12.043","article-title":"Genetic manipulation of the ApoF\/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis","volume":"233","year":"2014","journal-title":"Atherosclerosis"},{"key":"hep32631-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"380","DOI":"10.5551\/jat.13706","article-title":"Clinical significance of plasma apolipoprotein F in Japanese healthy and hypertriglyceridemic subjects","volume":"20","year":"2013","journal-title":"J Atheroscler Thromb"},{"key":"hep32631-bib-0040-20250824","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1194\/jlr.M700258-JLR200","article-title":"Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects","volume":"49","year":"2008","journal-title":"J Lipid Res"},{"key":"hep32631-bib-0041-20250824","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/s42255-021-00478-5","article-title":"Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases","volume":"3","year":"2021","journal-title":"Nat Metab"},{"key":"hep32631-bib-0042-20250824","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1161\/ATVBAHA.113.301637","article-title":"Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low\u2010density lipoprotein receptors depend on dietary conditions in mice","volume":"33","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep32631-bib-0043-20250824","doi-asserted-by":"crossref","first-page":"18602","DOI":"10.1074\/jbc.M702027200","article-title":"Binding of proprotein convertase subtilisin\/kexin type 9 to epidermal growth factor\u2010like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation","volume":"282","year":"2007","journal-title":"J Biol Chem"},{"key":"hep32631-bib-0044-20250824","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1161\/ATVBAHA.113.301517","article-title":"Hepatic cholesterol homeostasis","volume":"33","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"hep32631-bib-0045-20250824","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-019-0250-7","article-title":"Regulation of intestinal lipid metabolism: current concepts and relevance to disease","volume":"17","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep32631-bib-0046-20250824","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/eurheartj\/ehs431","article-title":"Genetically elevated non\u2010fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction","volume":"34","year":"2013","journal-title":"Eur Heart J"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.32631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.32631","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:09:14Z","timestamp":1756073354000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.32631","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"2021-12-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}