{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:25:44Z","timestamp":1794407144939,"version":"4.9.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>It is unclear if the leading causes of death in patients with NAFLD differ by age. We aimed to investigate if the relative importance of liver\u2010related deaths is lower and overshadowed by cardiovascular and cancer\u2010related deaths in the elderly population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>We conducted a territory\u2010wide retrospective cohort study of adult patients with NAFLD between 2000 and 2021 in Hong Kong. The outcomes of interest were all\u2010cause and cause\u2010specific mortality. Age groups at death were studied at 10\u2010year intervals. During 662,471 person\u2010years of follow\u2010up of 30,943 patients with NAFLD, there were 2097 deaths. The top three causes of death were pneumonia, extrahepatic cancer, and cardiovascular diseases. Liver disease was the sixth leading cause of death in patients aged 70\u201379 and 80\u201389\u2009years, accounting for 5.1% and 5.9% of deaths, respectively, but only accounted for 3% or fewer of the deaths in the other age groups. Nonetheless, liver disease was the leading cause of death in patients with NAFLD\u2010related cirrhosis, accounting for 36.8% of all deaths. The incidence of liver\u2010related death was higher in men younger than age 70 but higher in women afterwards. The incidence of liver\u2010related death in women increased from 0.62 to 7.14 per 10,000 person\u2010years from age 60\u201369 to 70\u201379\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The relative importance of liver\u2010related death increases with age in patients with NAFLD, especially among women. In patients with cirrhosis, liver disease is the leading cause of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32633","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T08:53:52Z","timestamp":1657011232000},"page":"573-584","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Age and the relative importance of liver\u2010related deaths in nonalcoholic fatty liver disease"],"prefix":"10.1097","volume":"77","author":[{"given":"Huapeng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-2464","authenticated-orcid":false,"given":"Terry Cheuk\u2010Fung","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-8904","authenticated-orcid":false,"given":"Xinrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Kit","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki Wing\u2010Ki","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy Che\u2010To","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-5480","authenticated-orcid":false,"given":"Stephen Lam","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Sir YK Pao Centre for Cancer, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Union Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-9389","authenticated-orcid":false,"given":"Grace Lai\u2010Hung","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-9410","authenticated-orcid":false,"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"Medical Data Analytics Centre, The Chinese University of Hong Kong, Hong Kong, China"},{"name":"State Key Laboratory of Digestive 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