{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:45:12Z","timestamp":1790628312496,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Recent studies suggest that mitochondrial dysfunction promotes progression to NASH by aggravating the gut\u2010liver status. However, the underlying mechanism remains unclear. Herein, we hypothesized that enhanced mitochondrial activity might reshape a specific microbiota signature that, when transferred to germ\u2010free (GF) mice, could delay NASH progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results:<\/jats:title>\n                    <jats:p>\n                      Wild\u2010type and methylation\u2010controlled J protein knockout (MCJ\u2010KO) mice were fed for 6\u2009weeks with either control or a choline\u2010deficient, L\u2010amino acid\u2013defined, high\u2010fat diet (CDA\u2010HFD). One mouse of each group acted as a donor of cecal microbiota to GF mice, who also underwent the CDA\u2010HFD model for 3\u2009weeks. Hepatic injury, intestinal barrier, gut microbiome, and the associated fecal metabolome were then studied. Following 6\u2009weeks of CDA\u2010HFD, the absence of methylation\u2010controlled J protein, an inhibitor of mitochondrial complex I activity, reduced hepatic injury and improved gut\u2010liver axis in an aggressive NASH dietary model. This effect was transferred to GF mice through cecal microbiota transplantation. We suggest that the specific microbiota profile of MCJ\u2010KO, characterized by an increase in the fecal relative abundance of\n                      <jats:italic toggle=\"yes\">Dorea<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Oscillospira<\/jats:italic>\n                      genera and a reduction in\n                      <jats:italic toggle=\"yes\">AF12<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Allboaculum<\/jats:italic>\n                      , and [\n                      <jats:italic toggle=\"yes\">Ruminococcus<\/jats:italic>\n                      ], exerted protective actions through enhancing short\u2010chain fatty acids, nicotinamide adenine dinucleotide (NAD\n                      <jats:sup>+<\/jats:sup>\n                      ) metabolism, and sirtuin activity, subsequently increasing fatty acid oxidation in GF mice. Importantly, we identified\n                      <jats:italic toggle=\"yes\">Dorea<\/jats:italic>\n                      genus as one of the main modulators of this microbiota\u2010dependent protective phenotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Overall, we provide evidence for the relevance of mitochondria\u2013microbiota interplay during NASH and that targeting it could be a valuable therapeutic approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32705","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T12:30:05Z","timestamp":1659529805000},"page":"1654-1669","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":65,"title":["Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression"],"prefix":"10.1097","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4678-3058","authenticated-orcid":false,"given":"Mar\u00eda","family":"Ju\u00e1rez\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Le\u00f3n, Spain"},{"name":"Biomedical Research Network on Liver and Digestive Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-028X","authenticated-orcid":false,"given":"Naroa","family":"Goikoetxea\u2010Usandizaga","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, 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Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-6384","authenticated-orcid":false,"given":"Marina","family":"Serrano\u2010Maci\u00e1","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0404-6244","authenticated-orcid":false,"given":"Jorge","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedical Research Network on Liver and Digestive Diseases (CIBERehd), Carlos III National Health Institute, Madrid, Spain"},{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-581X","authenticated-orcid":false,"given":"Teresa C.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-3664","authenticated-orcid":false,"given":"Sof\u00eda","family":"Lachiondo\u2010Ortega","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-8744","authenticated-orcid":false,"given":"Susana","family":"Mart\u00ednez\u2010Fl\u00f3rez","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine (IBIOMED), University of Le\u00f3n, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-6078","authenticated-orcid":false,"given":"\u00d3scar","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Vascular Pathology, IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz\u2010Universidad Aut\u00f3noma de Madrid, Madrid, Spain"},{"name":"Biomedical Research Network on Diabetes and Related Metabolic Diseases\u2010CIBERDEM, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Medicine, Immunobiology Division, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Varela\u2010Rey","sequence":"additional","affiliation":[{"name":"Biomedical Research Network on Liver and Digestive Diseases 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