{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:47:10Z","timestamp":1761126430040,"version":"3.30.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6786,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,2]]},"abstract":"\n ABSTRACT<\/jats:bold>\n <\/jats:title>\n \n \n \n Patients presenting with clinical and laboratory features consistent with a diagnosis of acute non\u2013A, non\u2013B hepatitis were evaluated for evidence of hepatitis C or hepatitis E infection and for evidence of severe or prolonged disease. Antibody to hepatitis C virus (anti\u2013HCV) was detected in 75 of 108 (69%) patients, antibody to hepatitis E virus (anti\u2013HEV) in three patients (3%), and neither antibody in 31 (29%) patients. One patient had both anti\u2013HCV and anti\u2013HEV. HCV RNA was not detected in sera from any of 20 patients with seronegative (non\u2013ABCDE) hepatitis, but in all 10 patients with anti\u2013HCV who were tested by polymerase chain reaction (PCR). Compared with patients with acute hepatitis C, those with non\u2013ABCDE hepatitis had a lower incidence of parenteral risk factors (6% vs. 70%;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .001), higher peak serum bilirubin levels (45% vs. 5% with peak levels > 15 mg\/dL;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .001), more prolonged jaundice (25% vs. 0% with peak bilirubin >5 weeks after onset;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .01), more severe prothrombin time abnormalities (26% vs. 0% with >3 second prolongation;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .001), more severe hypoalbuminemia (39% vs. 9% with albumin <3 g\/dL;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .01), and more frequent major clinical complications (13% vs. 0% with encephalopathy;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .01; 10% vs. 0% with death or transplant;<\/jats:bold>\n \n P\n <\/jats:bold>\n = .024). Patients with acute non\u2013ABCDE hepatitis were less likely to develop chronic hepatitis than those with acute hepatitis C (23% vs. 68%;<\/jats:bold>\n \n P\n <\/jats:bold>\n < .05). Thus, patients with acute non\u2013ABCDE hepatitis are epidemiologically distinct from those with acute hepatitis C and have a significantly more severe acute illness.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hep.510250237","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:03:50Z","timestamp":1090969430000},"page":"478-483","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Acute Sporadic Non\u2013A, Non\u2013B, Non\u2013C, Non\u2013D, Non\u2013E Hepatitis"],"prefix":"10.1097","volume":"25","author":[{"given":"F A","family":"Rochling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W F","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"DuCharme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L T","family":"Mimms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Scheffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Cuthbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.510250237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199702000-00037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:18:32Z","timestamp":1733051912000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199702000-00037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.510250237","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}