{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:18:20Z","timestamp":1792739900375,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6636,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Our aim was to investigate the time-related changes in various parameters following orthotopic rat liver transplantation with (AOLT) and without (NOLT) arterial reconstruction in male Lewis rats. Body weight and biochemical parameters were measured weekly, and a liver biopsy was obtained at 4, 8, and 12 weeks. Hemodynamics were evaluated at 12 weeks using the microsphere technique and compared with matched controls. Following AOLT, rats gained weight normally without any noticeable complication. In NOLT, two subgroups (NOLT-1 and NOLT-2) could clearly be identified retrospectively. In the NOLT-1 group, the body weight increased normally, although animals presented transient cholestasis. In these rats, the ductular proliferation found at 4 weeks had regressed by the 12th week with near-normal biopsies. By contrast, in the NOLT-2 group, rats did not gain body weight and had persistent cholestasis. Marked ductular proliferation with increasing fibrosis was observed, resulting in a secondary biliary cirrhosis by the 12th week. Surprisingly, rearterialization of the grafted liver occurred in both NOLT-1 and NOLT-2 irrespective of their clinical course. All transplanted rats showed portal hypertension with marked portosystemic shunts, probably caused by the portal cuff. However, a hyperdynamic circulatory state was only observed in the NOLT-2 group with cirrhotic changes. These findings further show the combined role of an intact hepatic innervation and of hepatocellular insufficiency in the genesis of the hyperdynamic circulatory state associated with portal hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510260126","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:15:44Z","timestamp":1090970144000},"page":"198-205","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Long-term consequence of rat orthotopic liver transplantation with and without hepatic arterial reconstruction: A clinical, pathological, and hemodynamic study"],"prefix":"10.1097","volume":"26","author":[{"given":"H","family":"Imamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Rocheleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P M","family":"Huet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.510260126-BIB1|cit1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00007890-197312000-00019","article-title":"A technique for orthotopic liver transplantation in the rat","volume":"16","author":"Lee","year":"1973","journal-title":"Transplantation"},{"key":"10.1002\/hep.510260126-BIB2|cit2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00007890-197907000-00011","article-title":"Orthotopic liver transplantation in the rat","volume":"28","author":"Kamada","year":"1979","journal-title":"Transplantation"},{"key":"10.1002\/hep.510260126-BIB3|cit3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/00007890-198903000-00005","article-title":"The importance of the hepatic artery in rat liver transplantation","volume":"47","author":"Howden","year":"1989","journal-title":"Transplantation"},{"key":"10.1002\/hep.510260126-BIB4|cit4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/hep.1840170224","article-title":"Morphometry of the liver after liver transplantation in the rat: significance of an intact arterial supply","volume":"17","author":"Zhao","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB5|cit5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-642-61657-0_12","volume-title":"Microsurgical Models in Rats for Transplantation Research","author":"Engemann","year":"1985"},{"key":"10.1002\/hep.510260126-BIB6|cit6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/00007890-198205000-00024","article-title":"Value of a physiological liver transplant model in rats","volume":"33","author":"Engemann","year":"1982","journal-title":"Transplantation"},{"key":"10.1002\/hep.510260126-BIB7|cit7","first-page":"195","article-title":"The value of hepatic artery reconstruction as a technique in rat liver transplantation","volume":"111","author":"Kamada","year":"1992","journal-title":"Surgery"},{"key":"10.1002\/hep.510260126-BIB8|cit8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000129164","article-title":"Effect of rearterialization on short-term graft function in orthotopic rat liver transplantation","volume":"23","author":"Svensson","year":"1991","journal-title":"Eur Surg Res"},{"key":"10.1002\/hep.510260126-BIB9|cit9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BFb0027689","article-title":"The function of hepatic artery","volume":"76","author":"Rappaport","year":"1976","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1002\/hep.510260126-BIB10|cit10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF01257260","article-title":"Bedeutung der arterialisation des trans-plantates bei rattenlebertransplantation","volume":"359","author":"Lie","year":"1983","journal-title":"Langenbecks Arch Chir"},{"key":"10.1002\/hep.510260126-BIB11|cit11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1432-2277.1994.tb01234.x","article-title":"Quantitative measurements of collateral arterial blood flow in nonarterialized rat liver grafts","volume":"7","author":"Svensson","year":"1994","journal-title":"Transplant Int"},{"key":"10.1002\/hep.510260126-BIB12|cit12","first-page":"1353","article-title":"Regression of bile duct damage and bile duct proliferation in the non-arterialized transplanted rat liver is associated with spontaneous graft rearterialization","volume":"21","author":"Zhao","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB13|cit13","first-page":"1257","article-title":"Primary biliary cirrhosis","volume":"60","author":"Scheuer","year":"1967","journal-title":"Proc R Soc Med"},{"key":"10.1002\/hep.510260126-BIB14|cit14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0300-5089(21)00111-5","article-title":"Morphological features: their usefulness in the diagnosis, prognosis and management of cirrhosis","volume":"4","author":"Baggenstoss","year":"1975","journal-title":"Clin Gastroenterol"},{"key":"10.1002\/hep.510260126-BIB15|cit15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/00007890-199203000-00050","article-title":"A modified cuff technique for suprahe-patic vena cava anastomosis in rat liver transplantation","volume":"53","author":"Harihara","year":"1992","journal-title":"Transplantation"},{"key":"10.1002\/hep.510260126-BIB16|cit16","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1097\/00007890-198804000-00039","article-title":"A simple method for orthotopic liver transplantation with arterial reconstruction in rats","volume":"45","author":"Hasuike","year":"1988","journal-title":"Transplantation"},{"key":"10.1002\/hep.510260126-BIB17|cit17","first-page":"G52","article-title":"Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension","volume":"244","author":"Vorobioff","year":"1983","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.510260126-BIB18|cit18","first-page":"G156","article-title":"Splanchnic hemodynamics in portal-hypertensive rats: measurement with g-labeled microsphere","volume":"242","author":"Groszmann","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.510260126-BIB19|cit19","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0016-5085(90)91030-A","article-title":"Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat","volume":"99","author":"Slott","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.510260126-BIB20|cit20","first-page":"G153","article-title":"Effect of orthotopic transplantation of liver on systemic and splanchnic hemodynamics in conscious rat","volume":"269","author":"Kuznetsova","year":"1995","journal-title":"AmJ Physiol"},{"key":"10.1002\/hep.510260126-BIB21|cit21","first-page":"364","volume-title":"Pathology of the Liver","author":"Desmet","year":"1987"},{"key":"10.1002\/hep.510260126-BIB22|cit22","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1172\/JCI102813","article-title":"The cardiac output at rest in La\u00e8nnec's cirrhosis","volume":"32","author":"Kowalski","year":"1953","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.510260126-BIB23|cit23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0002-9343(58)90322-X","article-title":"Circulatory changes in chronic liver disease","volume":"24","author":"Murray","year":"1958","journal-title":"Am J Med"},{"key":"10.1002\/hep.510260126-BIB24|cit24","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/hep.1840200537","article-title":"Hyperdynamic circulation in cirrhosis: a historical perspective","volume":"20","author":"Abelmann","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/hep.1840200538","article-title":"Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences","volume":"20","author":"Groszmann","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB26|cit26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0301-0082(83)90016-3","article-title":"Afferent and efferent neural roles in liver function","volume":"21","author":"Lautt","year":"1983","journal-title":"Prog Neurobiol"},{"key":"10.1002\/hep.510260126-BIB27|cit27","first-page":"G868","article-title":"Capsaicin treatment blocks development of hyper-kinetic circulation in portal hypertensive and cirrhotic rats","volume":"264","author":"Lee","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.510260126-BIB28|cit28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.1840070129","article-title":"Hemodynamic effects of clonidine-induced decrease in sympathetic tone in patients with cirrhosis","volume":"7","author":"Moreau","year":"1987","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB29|cit29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/hep.1840090217","article-title":"Serotonin blockade in conscious unrestrained cirrhotic dogs with portal hypertension","volume":"9","author":"Mastai","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/gut.25.10.1034","article-title":"Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis","volume":"25","author":"Henriksen","year":"1984","journal-title":"Gut"},{"key":"10.1002\/hep.510260126-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1136\/gut.27.10.1204","article-title":"Influence of the degree of liver failure on systemic and splanchnic haemodynamics and on response to propranol in patients with cirrhosis","volume":"27","author":"Braillon","year":"1986","journal-title":"Gut"},{"key":"10.1002\/hep.510260126-BIB32|cit32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/hep.1840150224","article-title":"Temporal relationship of peripheral vasodilatation: plasma volume expansion and the hyperdynamic circulatory state in portal hypertension rats","volume":"15","author":"Colombato","year":"1992","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260126-BIB33|cit33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.1840060315","article-title":"Hemodynamic studies in long- and short-term portal hypertensive rats: the relation to systemic glucagon levels","volume":"6","author":"Sikuler","year":"1986","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.510260126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199707000-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:20:50Z","timestamp":1738941650000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199707000-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.510260126","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}