{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:30Z","timestamp":1792839750220,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement 3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6483,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In the United States, the annual number of newly acquired acute hepatitis C virus (HCV) infections has declined from an estimated 180,000 in the mid 1980s to an estimated 28,000 in 1995. Approximately 25% to 30% of these infections are clinically apparent cases that are sufficiently symptomatic to gain medical attention. Deaths from fulminant hepatitis C are rare. The prevalence of antibody to HCV (anti- HCV) in the general population of the United States is 1.8%, corresponding to an estimated 3.9 million Americans infected with HCV, and an estimated 8,000 to 10,000 deaths each year result from HCV- associated chronic liver disease. HCV infection affects persons of all ages, but most acute cases of hepatitis C and the highest prevalence of anti-HCV are found among young adults. The highest proportion both of incident cases and prevalent infections is among whites, but the highest incidence and prevalence rates are among non-white racial\/ethnic groups. In the past, transfusion of blood and blood products was an important source of HCV transmission, but currently, high-risk drug and sexual exposures account for most HCV transmission. Although the incidence of acute hepatitis C has declined, there is a large reservoir of chronically infected Americans who can serve as a source of transmission to others and who are at risk of the severe consequences of chronic liver disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510260711","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:41:22Z","timestamp":1090971682000},"page":"62S-65S","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":701,"title":["Epidemiology of hepatitis C"],"prefix":"10.1097","volume":"26","author":[{"given":"M J","family":"Alter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.510260711","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199712003-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:42:53Z","timestamp":1738942973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199712003-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":0,"journal-issue":{"issue":"Supplement 3","published-print":{"date-parts":[[1997]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.510260711","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}