{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:49:50Z","timestamp":1791121790129,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6393,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Few data are available to evaluate the performance of existing assays for antibody to the hepatitis E virus (anti-HEV). A panel of 164 randomized and coded sera was tested for anti-HEV by 12 different assays. The panel included a dilution series of an early convalescent human serum, known-positive sera (undiluted human sera obtained 2 months to 13 years after acute hepatitis E, and postinoculation chimpanzee sera), known-negative sera (preinoculation chimpanzee sera; sera from chimpanzees with hepatitis A virus, hepatitis B virus, or hepatitis C virus infection; and normal human sera), and sera obtained from previously tested U.S. blood donors without a history of hepatitis. Six tests detected anti-HEV in \u226590% of undiluted known-positive sera. The sensitivity of all of the assays with known-positive sera ranged from 17% to 100%, and the limit of detection by endpoint dilution ranged from 1:5 to 1:160. Ten tests were nonreactive for all of the 22 known-negative sera, one test was reactive for one serum, and one test was reactive for 5 sera. In pairwise comparisons of different tests in blood donor sera, the overall concordance ranged from 49% to 94% (median, 69%) and the concordance among reactive sera ranged from 0% to 89% (median, 32%). Several of these tests performed well in detecting anti-HEV in known positive sera. However, highly discrepant results among U.S. blood donor sera indicate that anti-HEV seroprevalence data in non-HEV-endemic countries may be unreliable and should be interpreted with caution.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510270331","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:44:28Z","timestamp":1090971868000},"page":"857-861","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":186,"title":["Evaluation of assays for antibody to hepatitis E virus by a serum panel"],"prefix":"10.1097","volume":"27","author":[{"given":"Eric E.","family":"Mast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam J.","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul V.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000149370","volume":"20","author":"Balayan","year":"1983","journal-title":"Intervirology"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1001\/jama.1984.03350220046029","volume":"252","author":"Kane","year":"1984","journal-title":"JAMA"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/infdis\/159.6.1042","volume":"159","author":"Krawczynski","year":"1989","journal-title":"J Infect Dis"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jmv.1890440217","volume":"44","author":"Purdy","year":"1994","journal-title":"J Med Virol"},{"key":"BIB5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01317268","volume":"123","author":"Purdy","year":"1992","journal-title":"Arch Virol"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jmv.1890360403","volume":"36","author":"Favorov","year":"1992","journal-title":"J Med Virol"},{"key":"BIB7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0166-0934(92)90180-L","volume":"38","author":"Dawson","year":"1992","journal-title":"J Virol Methods"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/infdis\/168.2.369","volume":"168","author":"Tsarev","year":"1993","journal-title":"J Infect Dis"},{"key":"BIB9","first-page":"94","volume":"43","author":"Uchida","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0166-0934(94)90106-6","volume":"46","author":"Favorov","year":"1994","journal-title":"J Virol Methods"},{"key":"BIB11","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1128\/JCM.32.9.2060-2066.1994","volume":"32","author":"Li","year":"1994","journal-title":"J Clin Microbiol"},{"key":"BIB12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/978-4-431-68255-4_92","volume-title":"Viral hepatitis and liver disease","author":"Yarbough","year":"1994","unstructured":"et al. 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