{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:08:07Z","timestamp":1773770887874,"version":"3.50.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6148,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Patency and direction of flow in portal veins and their branches are generally assessed by duplex Doppler ultrasonography (DDUS), whereas few data are available on hepatic arterial hemodynamics. In this study, resistive (RI) and pulsatility indexes (PI) were calculated at DDUS in 21 controls, 22 chronic alcoholic patients without evidence of liver damage, 19 patients with acute alcoholic hepatitis (AAH), 30 patients with chronic viral hepatitis (CVH), 23 patients with alcoholic cirrhosis, and 22 patients with viral\u2013related cirrhosis. Diagnosis was based on clinical and histological findings. Mean \u00b1 SD RI was similar in controls and CVH patients (0.64 \u00b1 0.02 and 0.66 \u00b1 0.04, respectively), significantly decreased in alcoholic patients without liver damage and AAH patients (0.61 \u00b1 0.07 and 0.60 \u00b1 0.07) (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05), and significantly increased in patients with alcoholic (0.72 \u00b1 0.04) and viral\u2013related cirrhosis (0.74 \u00b1 0.04) (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). It was &lt;0.60 in 9 of the 19 AAH patients (47%) and 11 of the 22 alcoholic patients without liver damage (50%), and &gt;0.70 in 39 of the 45 cirrhotic patients (87%) and 12 of the 71 noncirrhotic patients pooled together (17%). A significant correlation was observed between RI and PI (<jats:italic toggle=\"yes\">r<\/jats:italic> = .83; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). The coefficients of variation for intraobserver variability were 6.3% \u00b1 5.1% for RI and 10.1% \u00b1 6.2% for PI, and the corresponding figures for interobserver variability were 5.2% \u00b1 3.5% and 9.3% \u00b1 4.6%. These findings support the existence of ethanol\u2013related hepatic arterial vasodilation in AAH and alcoholic patients without liver damage. Progression of liver damage from AAH to cirrhosis profoundly impairs the hepatic responsiveness as a consequence of fibrosis with vascular distortion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510280503","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:30:02Z","timestamp":1090971002000},"page":"1182-1186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":45,"title":["Hepatic Artery Resistance in Alcoholic Liver Disease"],"prefix":"10.1097","volume":"28","author":[{"given":"Agostino","family":"Colli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Cocciolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Mumoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Cattalini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirella","family":"Fraquelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1148\/radiology.154.2.3880913","volume":"15","author":"Taylor","year":"1985","journal-title":"Radiology"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1148\/radiology.162.1.3538152","volume":"162","author":"Alpern","year":"1987","journal-title":"Radiology"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1148\/radiology.179.2.2014284","volume":"179","author":"Platt","year":"1991","journal-title":"Radiology"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1148\/radiology.187.2.8475308","volume":"187","author":"Colli","year":"1993","journal-title":"Radiology"},{"key":"BIB5","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/0016-5085(95)90214-7","volume":"108","author":"Sacerdoti","year":"1995","journal-title":"Gastroenterology"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1148\/radiology.196.2.7617865","volume":"196","author":"Joynt","year":"1995","journal-title":"Radiology"},{"key":"BIB7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1148\/radiology.200.3.8756933","volume":"200","author":"Iwao","year":"1996","journal-title":"Radiology"},{"key":"BIB8","first-page":"146a","volume":"24","author":"Han","year":"1996","journal-title":"Hepatology"},{"key":"BIB9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.7326\/0003-4819-79-5-625","volume":"79","author":"Campra","year":"1973","journal-title":"Ann Intern Med"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg"},{"key":"BIB11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hep.1840200104","volume":"20","author":"The French","year":"1994","journal-title":"Hepatology"},{"key":"BIB12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1148\/radiology.174.2.2404309","volume":"174","author":"Taylor","year":"1990","journal-title":"Radiology"},{"key":"BIB13","volume-title":"Statistical Methods in Medical Research.","author":"Armitage","year":"1971","unstructured":"Statistical Methods in Medical Research. 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