{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:27:42Z","timestamp":1790897262655,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6056,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Both CCAAT\/enhancer binding protein \u03b1 (C\/EBP\u03b1) and C\/EBP\u03b2 are intronless, yet can create various N\u2013terminally truncated protein products with distinct DNA binding and transactivation potentials. These proteins can be generated via two distinct mechanisms, one translational and the other post\u2013translational. In the translational mechanism, there is alternative translational start site selection of the different AUG codons present in the single messenger RNA (mRNA) species via a process of leaky ribosome scanning. Additionally, a post\u2013translational method of isoform formation, through specific proteolytic cleavage of the full length protein has also been described. In this manuscript, we present evidence that the production of C\/EBP\u03b2 protein isoforms in the neonatal mouse liver is regulated by C\/EBP\u03b1. In C\/EBP\u03b1 knockout mice, the predominant C\/EBP\u03b2 proteins are the larger 38\u2013 and 35\u2013kd isoforms, whereas wild\u2013type animals primarily possess the smaller 21\u2013 and 14\u2013kd isoforms. These C\/EBP\u03b1\u2013dependent differences are liver specific, not present in lung or adipose tissues, and present at day 18 of development. Additionally, we show that induction of C\/EBP\u03b1 expression leads to an increase in the production of the 21\u2013kd C\/EBP\u03b2 isoform in cell culture studies. As the various C\/EBP\u03b2 protein isoforms have different transcriptional capabilities, it is important to understand the regulation of the production of these isoforms. Our observations suggest a novel role for the C\/EBP\u03b1 transcription factor in this process.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510290245","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:39:45Z","timestamp":1090971585000},"page":"597-601","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Ccaat\/Enhancer Binding Protein \u03b1 (C\/Ebp\u03b1) Is An Important Mediator of Mouse C\/Ebp\u03b2 Protein Isoform Production"],"prefix":"10.1097","volume":"29","author":[{"given":"Bonnie L.","family":"Burgess-Beusse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai A.","family":"Timchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen 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