{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:57:26Z","timestamp":1765666646542,"version":"3.30.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5967,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Patients with primary biliary cirrhosis (PBC) may be at increased risk for malignancies. Several studies have addressed the risk of specific malignancies; however, there is little information about overall incidences of malignancies in these patients. We hypothesize that these patients may be at an increased risk for cancer. We performed a retrospective chart review evaluating patients with the diagnosis of PBC and malignancies. We reviewed records of patients with PBC presenting to the Mayo Clinic between 1976 and 1985. The diagnosis of PBC was made using evidence of cholestasis, positive antimitochondrial antibody titers and liver biopsy findings consistent with PBC. The incidence of malignancies were then compared with published data by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. Of the 1,692 patients with PBC in the Mayo Clinic data base, 114 patients were identified with primary cancer. The number of malignancies was higher than would be anticipated by chance alone; with 93 observed versus 62.4 expected events (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001). Hepatobiliary malignancies had a relative risk of 46 (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .0001) for women and 55 (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .0001) in men. There was a dramatic increased risk for development of hepatobiliary malignancies. PBC patients might benefit from more aggressive surveillance for hepatobiliary malignancies during their lifetime<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510290511","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T07:46:44Z","timestamp":1091000804000},"page":"1396-1398","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":79,"title":["Incidence of Cancer in Primary Biliary Cirrhosis: the Mayo Experience"],"prefix":"10.1097","volume":"29","author":[{"given":"Pardeep K.","family":"Nijhawan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry M.","family":"Therneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolland E.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Boynton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D.","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(70)91737-X","volume":"1","author":"Sherlock","year":"1970","journal-title":"Lancet"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","volume":"2","author":"Beasley","year":"1981","journal-title":"Lancet"},{"key":"BIB3","first-page":"91","volume-title":"Etiology, Pathology and Treatment of Hepatocellular Carcinoma in North America","author":"Ishak","year":"1991","unstructured":"Hepatocellular carcinoma associated with the inherited metabolic diseases. In: eds. Etiology, Pathology and Treatment of Hepatocellular Carcinoma in North America. Portfolio Publishing Co. 1991;91-106."},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0168-8278(05)80307-1","volume":"21","author":"Farinati","year":"1994","journal-title":"J Hepatol"},{"key":"BIB5","first-page":"359","volume":"32","author":"Kaplan","year":"1987","journal-title":"Adv Intern Med"},{"key":"BIB6","first-page":"335","volume":"9","author":"Vento","year":"1990","journal-title":"Prog Liver Dis"},{"key":"BIB7","first-page":"377","volume-title":"Disease of the Liver","volume":"1","author":"Kaplan","year":"1993","unstructured":"Primary biliary cirrhosis. In: eds. Disease of the Liver. Volume 1. 7th ed. 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