{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:32:39Z","timestamp":1791045159846,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5936,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"PHRC, Assistance Publique-H\u00f4pitaux de Paris","award":["AOM 96045"],"award-info":[{"award-number":["AOM 96045"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Ursodeoxycholic acid (UDCA) treatment has been shown to increase survival without orthotopic liver transplantation (OLT) in patients with primary biliary cirrhosis (PBC) at 4 years. Whether this beneficial effect was maintained over the long term remained to be established. In a large cohort of UDCA\u2013treated patients with PBC, we aimed to determine the 10\u2013year outcome of these patients using two endpoints: (1) survival without OLT, and (2) survival. The cohort was comprised of 225 patients with PBC treated with UDCA (13\u201315 mg\/kg\/d) monitored from the beginning of treatment until time of last follow\u2013up, OLT, or death. Because of the absence of a control group, survival without OLT was compared with survival predicted by the Mayo model (first 7 years), and observed 10\u2013year survival with an estimation of survival of a standardized control cohort of the French population. Observed survival without OLT of UDCA\u2013treated patients was significantly higher (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .04) than survival predicted by the Mayo model. Observed survival was significantly lower (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01) than survival predicted from the French population. Observed survival of noncirrhotic patients was not different (<jats:italic toggle=\"yes\">P<\/jats:italic> &gt; .9) from that of the French control population but survival of cirrhotic patients was significantly lower (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .0001). Twenty\u2013two patients died; 13 patients died of hepatic causes and 4 patients died after OLT. In conclusion, survival without OLT among patients treated with UDCA for PBC is higher than that of untreated patients, as predicted by the Mayo model. Ten\u2013year survival among UDCA\u2013treated patients is slightly lower than that of an age\u2013 and sex\u2013matched general population, the difference mainly being explained by mortality among cirrhotic patients<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510290603","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T07:25:40Z","timestamp":1090999540000},"page":"1668-1671","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":168,"title":["Ten\u2013Year Survival in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cirrhosis"],"prefix":"10.1097","volume":"29","author":[{"given":"Ren\u00e9e Eug\u00e9nie","family":"Poupon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Bonnand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Chr\u00e9tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Poupon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.510290603-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJM199105303242204","article-title":"A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. the UDCA-PBC Study Group","volume":"324","author":"Poupon","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.510290603-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/0016-5085(94)90021-3","article-title":"Ursodeoxycholic acid in the treatment of primary biliary cirrhosis","volume":"106","author":"Lindor","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.510290603-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/hep.1840190512","article-title":"The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis","volume":"19","author":"Heathcote","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/hep.510290603-BIB4|cit4","first-page":"759","article-title":"A randomized, double-blind, placebo-controlled trial of ursodeoxycholate in primary biliary cirrhosis","volume":"22","author":"Combes","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/hep.510290603-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM199405123301903","article-title":"Ursodiol for the long-term treatment of primary biliary cirrhosis. the UDCA-PBC Study Group","volume":"330","author":"Poupon","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.510290603-BIB6|cit6","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0016-5085(97)70183-5","article-title":"Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis","volume":"113","author":"Poupon","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.510290603-BIB7|cit7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0168-8278(94)80111-8","article-title":"Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis","volume":"21","author":"Leuschner","year":"1994","journal-title":"J Hepatol"},{"key":"10.1002\/hep.510290603-BIB8|cit8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840100102","article-title":"Prognosis in primary biliary cirrhosis: model for decision making","volume":"10","author":"Dickson","year":"1989","journal-title":"Hepatology"},{"key":"10.1002\/hep.510290603-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/S0016-5085(96)70051-3","article-title":"Survival in ursodeoxycholic acid-treated patients with primary biliary cirrhosis [Letter]","volume":"111","author":"Lindor","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.510290603-BIB10|cit10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.510280203","article-title":"Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy","volume":"28","author":"Chazouill\u00e8res","year":"1998","journal-title":"Hepatology"},{"key":"10.1002\/hep.510290603-BIB11|cit11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00432479","article-title":"Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)","volume":"379","author":"Ludwig","year":"1978","journal-title":"Virchows Arch"},{"key":"10.1002\/hep.510290603-BIB12|cit12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non-parametric estimation from incomplete samples","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Amer Statist Assoc"},{"key":"10.1002\/hep.510290603-BIB13|cit13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2307\/2530150","article-title":"Rank tests and a one-sample log rank test for comparing observed survival data to a standard population","volume":"37","author":"Woolson","year":"1981","journal-title":"Biometrics"},{"key":"10.1002\/hep.510290603-BIB14|cit14","doi-asserted-by":"crossref","unstructured":"1987-1994","DOI":"10.18356\/be8e9049-en"},{"issue":"Suppl","key":"10.1002\/hep.510290603-BIB15|cit15","first-page":"166","article-title":"Long-term treatment of primary biliary cirrhosis with ursodeoxycholic acid: results of a randomized, double-blind, placebo-controlled trial [Abstract]. for the Spanish Association for the Study of the Liver","volume":"26","author":"Par\u00e8s","year":"1997","journal-title":"J Hepatol"},{"key":"10.1002\/hep.510290603-BIB16|cit16","unstructured":"Heathcote EJ Cauch-Dudek K Stone J Poupon R Chazouill\u00e8res O Lindor KD Petz J Liver Transpl Surg 1999"},{"key":"10.1002\/hep.510290603-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/0016-5085(95)90696-7","article-title":"A placebo-controlled trial of primary biliary cirrhosis treatment with colchicine and ursodeoxycholic acid","volume":"108","author":"Vuoristo","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.510290603-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/hep.510240520","article-title":"A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis. the UDCA-PBC Study Group","volume":"24","author":"Poupon","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/hep.510290603-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.510260508","article-title":"Hepatocellular carcinoma in primary biliary cirrhosis and its impact on outcomes","volume":"26","author":"Jones","year":"1997","journal-title":"Hepatology"},{"key":"10.1002\/hep.510290603-BIB20|cit20","first-page":"241","volume-title":"Bile acids and Immunology","author":"Poupon","year":"1997"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.510290603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199906000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:27:33Z","timestamp":1733052453000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199906000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.510290603","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}