{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:08:16Z","timestamp":1785355696976,"version":"3.55.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5936,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Bile acid composition in fasting duodenal bile was assessed at entry and at 2 years in patients with primary biliary cirrhosis (PBC) enrolled in a randomized, double\u2013blind, placebo\u2013controlled trial of ursodeoxycholic acid (UDCA) (10\u201312 mg\/kg\/d) taken as a single bedtime dose. Specimens were analyzed by a high\u2013pressure liquid chromatography method that had been validated against gas chromatography. Percent composition in bile (mean \u00b1 SD) for 98 patients at entry for cholic (CA), chenodeoxycholic (CDCA), deoxycholic (DCA), lithocholic (LCA), and ursodeoxycholic (UDCA) acids, respectively, were 57.4 \u00b1 18.6, 31.5 \u00b1 15.5, 8.0 \u00b1 9.3, 0.3 \u00b1 1.0, and 0.6 \u00b1 0.9. Values for CA were increased, whereas those for CDCA, DCA, LCA, and UDCA were decreased when compared with values in normal persons. Bile acid composition of the major bile acids did not change after 2 years on placebo medication. By contrast, in patients receiving UDCA for 2 years, bile became enriched with UDCA on average to 40.1%, and significant decreases were noted for CA (to 32.2%) and CDCA (to 19.5%). No change in percent composition was observed for DCA and LCA. Percent composition at entry and changes in composition after 2 years on UDCA were similar in patients with varying severity of PBC. In patients whose bile was not enriched in UDCA (entry and placebo\u2013treated specimens), CA, CDCA, DCA, and the small amount of UDCA found in some of these specimens were conjugated to a greater extent with glycine (52%\u201364%) than with taurine (36%\u201348%). Treatment with UDCA caused the proportion of all endogenous bile acids conjugated with glycine to increase to 69% to 78%, while the proportion conjugated with taurine (22%\u201331%) fell (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). Administered UDCA was also conjugated predominantly with glycine (87%)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510290618","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T07:25:40Z","timestamp":1090999540000},"page":"1649-1654","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":47,"title":["Biliary Bile Acids in Primary Biliary Cirrhosis: Effect of Ursodeoxycholic Acid"],"prefix":"10.1097","volume":"29","author":[{"given":"Burton","family":"Combes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Carithers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willis C.","family":"Maddrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Garcia-Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory F.","family":"Bonner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velimir A.","family":"Luketic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell L.","family":"Shiffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion G.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowen K.","family":"Zetterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Risser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan F.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/BF01295917","volume":"38","author":"Mazzella","year":"1993","journal-title":"Dig Dis Sci"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0168-8278(96)80293-5","volume":"25","author":"Van de Meeberg","year":"1996","journal-title":"J Hepatol"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/hep.1840140609","volume":"14","author":"Crosignani","year":"1991","journal-title":"Hepatology"},{"key":"BIB4","first-page":"691","volume":"88","author":"Batta","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"BIB5","first-page":"759","volume":"22","author":"Combes","year":"1995","journal-title":"Hepatology"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00432479","volume":"379","author":"Ludwig","year":"1978","journal-title":"Virchows Arch"},{"key":"BIB7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-2275(20)38684-3","volume":"28","author":"Rossi","year":"1987","journal-title":"J Lipid Res"},{"key":"BIB8","first-page":"454","volume":"14","author":"Fisher","year":"1991","journal-title":"Hepatology"},{"key":"BIB9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0016-5085(77)80318-1","volume":"72","author":"Hoffman","year":"1977","journal-title":"Gastroenterology"},{"key":"BIB10","first-page":"141","volume-title":"Biostatistical Analysism","author":"Zar","unstructured":"Biostatistical Analysism. 3rd ed. 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