{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:20:38Z","timestamp":1789780838053,"version":"4.0.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5906,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Ischemia\/reperfusion injury of the liver requires the participation of proinflammatory cytokines, chemokines, and adhesion molecules, many of which are regulated by the transcription factor nuclear factor \u03baB (NF\u03baB). The anti-inflammatory cytokine, interleukin-10 (IL-10) affects inflammatory reactions, at least in part, through inhibitory effects on the transcription factor, NF\u03baB. The objective of the current study was to determine whether IL-10 could suppress hepatic ischemia\/reperfusion-induced NF\u03baB activation and the ensuing inflammatory liver injury. C57BL\/6 mice underwent partial hepatic ischemia and reperfusion with or without intravenous injections of recombinant murine IL-10. Hepatic NF\u03baB activation was induced in a time-dependent fashion. IL-10 suppressed NF\u03baB activation as well as messenger RNA expression of tumor necrosis factor-\u03b1 (TNF-\u03b1) and macrophage inflammatory protein-2 (MIP-2). In addition, IL-10 reduced serum levels of TNF-\u03b1 and MIP-2. Hepatic neutrophil recruitment, liver edema, and hepatocellular injury were all significantly reduced by IL-10. The data suggest that IL-10 protects against hepatic ischemia\/reperfusion injury by suppressing NF\u03baB activation and subsequent expression of proinflammatory mediators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.510300120","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T03:26:03Z","timestamp":1090985163000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":181,"title":["Interleukin-10 suppresses hepatic ischemia\/reperfusion injury in mice: Implications of a central role for nuclear factor \u03baB"],"prefix":"10.1097","volume":"30","author":[{"given":"Hiroyuki","family":"Yoshidome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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