{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:10:31Z","timestamp":1789002631564,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5753,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Recombinant human interleukin-11 (rhIL-11) is a multifunctional cytokine that can reduce inflammation through the downregulation of multiple pro-inflammatory mediators from activated macrophages. rhIL-11 also inhibits production of several immunostimulatory cytokines such as IL-12 and interferon \u03b3 (IFN-\u03b3) and has shown biological activity in multiple animal models of inflammatory disease consistent with immunomodulatory effects on macrophages and T cells. To further elucidate the anti-inflammatory activity of rhIL-11 <jats:italic toggle=\"yes\">in vivo<\/jats:italic>, the effect of rhIL-11 in a model of Concanavalin A (Con-A)-induced T-cell-mediated hepatotoxicity was examined. Administration of a single dose of rhIL-11 before Con-A administration reduced centrilobular liver necrosis and enhanced survival. A dose-dependent reduction in serum levels of liver enzymes, tumor necrosis factor \u03b1 (TNF-\u03b1), and IFN-\u03b3 corresponded with this amelioration of liver damage. No significant change in infiltrating lymphocyte populations in the liver was observed following rhIL-11 treatment. Taken together, these results indicate that rhIL-11 ameliorates T-cell-mediated hepatic injury and suggests its therapeutic potential to treat inflammatory liver disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510300616","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T07:41:30Z","timestamp":1091000490000},"page":"1441-1447","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":67,"title":["Interleukin-11 reduces T-cell-dependent experimental liver injury in mice"],"prefix":"10.1097","volume":"30","author":[{"given":"Mary","family":"Bozza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L.","family":"Bliss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Maylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Page","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Trepicchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.4049\/jimmunol.157.8.3627","volume":"157","author":"Trepicchio","year":"1996","journal-title":"J Immunol"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.4049\/jimmunol.157.4.1705","volume":"157","author":"Redlich","year":"1996","journal-title":"J Immunol"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.4049\/jimmunol.159.11.5661","volume":"159","author":"Trepicchio","year":"1997","journal-title":"J Immunol"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1182\/blood.V80.11.2797.bloodjournal80112797","volume":"80","author":"Anderson","year":"1992","journal-title":"Blood"},{"key":"BIB5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.175.1.211","volume":"175","author":"Yin","year":"1992","journal-title":"J Exp Med"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI3132","volume":"102","author":"Hill","year":"1998","journal-title":"J Clin Invest"},{"key":"BIB7","first-page":"79","volume":"1","author":"Keith","year":"1994","journal-title":"Stem Cells"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1128\/IAI.64.3.714-718.1996","volume":"64","author":"Barton","year":"1996","journal-title":"Infect Immun"},{"key":"BIB9","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.4049\/jimmunol.159.5.2161","volume":"159","author":"Leng","year":"1997","journal-title":"J Immunol"},{"key":"BIB10","first-page":"256","volume-title":"The Lectins: Properties, functions and applications in biology and medicine","author":"Lis","year":"1986","unstructured":"Biological properties of lectin. 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