{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:28:36Z","timestamp":1791347316419,"version":"4.3.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5722,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Liver toxicity is a common side effect of antituberculosis (anti-TB) drugs. We studied the differences in liver dysfunction observed during anti-TB treatment between hepatitis B virus carriers (HBV) and noncarriers. Three hundred twenty-four patients on anti-TB drugs were recruited and followed up for 1 year. Forty-three patients with HBV and 276 non-HBV patients were included for analysis. Liver function tests and viral markers were monitored monthly. Liver biopsy was requested whenever the alanine transaminase (ALT) was persistently abnormal. Eighty-six HBV carriers who were not given anti-TB drugs were chosen as a second control and evaluated prospectively. The incidence of liver dysfunction was significantly higher in HBV carriers given anti-TB drugs (34.9%) when compared to noncarriers (9.4%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001) and with HBV carriers not given anti-TB drugs (8.1%, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001). For patients given anti-TB drugs, HBV carriers who developed liver dysfunction were younger (<jats:italic toggle=\"yes\">P<\/jats:italic> = .011) and had more severe liver injury compared with noncarriers (<jats:italic toggle=\"yes\">P<\/jats:italic> = .008). By multiple logistic regression analysis, age (<jats:italic toggle=\"yes\">P<\/jats:italic> = .002) and hepatitis B infection (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001) were the only 2 significant risk factors for hepatotoxicity related to anti-TB therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510310129","type":"journal-article","created":{"date-parts":[[2004,7,28]],"date-time":"2004-07-28T07:42:03Z","timestamp":1091000523000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":194,"title":["Antituberculosis drug-related liver dysfunction in chronic hepatitis B infection"],"prefix":"10.1097","volume":"31","author":[{"given":"Wai-Man","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui-Chee","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Fung","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Wai","family":"Yew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poon-Chuen","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk-Ming","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chiu","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lung","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.510310129-BIB1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1001\/jama.1994.03520070055038","volume":"272","author":"Cantwell","year":"1994","journal-title":"JAMA"},{"key":"10.1002\/hep.510310129-BIB2","first-page":"365","volume":"45","year":"1996","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1002\/hep.510310129-BIB3","unstructured":"Chest Service of the Department of Health, Hong Kong. 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