{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:41:11Z","timestamp":1781264471647,"version":"3.54.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Communications"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>We report a novel association between the commonly used antimalarial medication atovaquone\/proguanil and drug\u2010induced autoimmune\u2010like hepatitis. The patient developed severe liver disease fulfilling biochemical, immunologic, and histologic criteria for the diagnosis of autoimmune hepatitis after the inadvertent rechallenge with the offending drug, which had caused self\u2010limited hepatitic symptoms a year previously. Over a period of 18 months, the patient underwent two follow\u2010up liver biopsies showing progressive resolution of the liver inflammation and achieved complete biochemical and immunologic remission on steroids. This remission persisted for 20 months following treatment withdrawal.<jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: This well documented case raises awareness of the potential hepatotoxicity of atovaquone\/proguanil. (<jats:italic toggle=\"yes\">Hepatology Communications<\/jats:italic>2017;1:293\u2013298)<\/jats:p>","DOI":"10.1002\/hep4.1039","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T14:02:40Z","timestamp":1494252160000},"page":"293-298","source":"Crossref","is-referenced-by-count":10,"title":["Atovaquone\/proguanil\u2010induced autoimmune\u2010like hepatitis"],"prefix":"10.1097","volume":"1","author":[{"given":"Benedetta","family":"Terziroli Beretta\u2010Piccoli","sequence":"first","affiliation":[{"name":"Epatocentro Ticino,Lugano,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina","family":"Mieli\u2010Vergani","sequence":"additional","affiliation":[{"name":"Paediatric Liver, GI and Nutrition Centre,King's College Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaela","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Regional Pharmacovigilance Center, 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