{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:19:03Z","timestamp":1770070743702,"version":"3.49.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Communications"],"published-print":{"date-parts":[[2018,2,2]]},"abstract":"<jats:p>Patients with end\u2010stage liver disease develop acute decompensation (AD) episodes, which become more frequent and might develop into acute\u2010on\u2010chronic liver failure (ACLF). However, it remains unknown how AD induces acceleration of liver disease. We hypothesized that remodeling of collagen type III plays a role in the acceleration of liver cirrhosis after AD and analyzed its formation (Pro\u2010C3) and degradation (matrix metalloproteinase\u2010degraded type III collagen [C3M]) markers in animal models and human disease. Bile duct ligation induced different stages of liver fibrosis in rats. Fibrosis development (hydroxyprolin content, sirius red staining, \u03b1\u2010smooth muscle actin immunohistochemistry, messenger RNA of profibrotic cytokines), necroinflammation (aminotransferases levels), fibrolysis (matrix metalloproteinase 2 expression and activity, C1M, C4M), and Pro\u2010C3 and C3M were analyzed 2, 3, 4, 5, and 6 weeks after bile duct ligation (n = 5 each group). In 110 patients with decompensated liver cirrhosis who underwent a transjugular intrahepatic portosystemic shunt procedure for AD, clinical and laboratory parameters as well as Pro\u2010C3 and C3M were measured in blood samples from portal and hepatic veins and were collected just before the transjugular intrahepatic portosystemic shunt placement and 1\u20103 weeks later. Animal studies showed increased markers of collagen type III deposition with fibrosis, necroinflammation, and decompensation of liver cirrhosis, defined as ascites development. Higher Pro\u2010C3 levels were associated with injury, disease severity scores (Model for End\u2010Stage Liver Disease, Child\u2010Pugh, chronic liver failure\u2010C AD), ACLF development, and mortality. C3M decreased with AD and the chronic liver failure\u2010C AD score. Collagen type III deposition ratio increased with the risk of ACLF development and mortality. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> We show for the first time that AD boosts collagen type III deposition in experimental and human cirrhosis, possibly contributing to the worsened outcome in patients with decompensated cirrhosis. (<jats:italic toggle=\"yes\">Hepatology Communications<\/jats:italic> 2018;2:211\u2013222)<\/jats:p>","DOI":"10.1002\/hep4.1135","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T05:06:44Z","timestamp":1516252004000},"page":"211-222","source":"Crossref","is-referenced-by-count":46,"title":["Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis"],"prefix":"10.1097","volume":"2","author":[{"given":"Michael","family":"Praktiknjo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette J.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Nordic 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