{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:48:30Z","timestamp":1740178110164,"version":"3.37.3"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Communications"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Immunoglobulin G4 (IgG4)\u2010related disease is a fibroinflammatory systemic disorder with multiorgan involvement. Proximal bile duct involvement results in IgG4\u2010related sclerosing cholangitis, which is characterized by a lymphoplasmacytic infiltrate with abundant IgG4\u2010positive plasma cells and fibrosis. Differentiating between cholangiocarcinoma and IgG4\u2010sclerosing cholangitis can present a diagnostic dilemma. We describe an unusual presentation of a hepatic mass meeting multiple criteria for IgG4\u2010sclerosing cholangitis but was ultimately found to be cholangiocarcinoma. Several published case reports describe patients with suspected cholangiocarcinoma who are later found to have IgG4\u2010sclerosing cholangitis, but few reports have demonstrated the reverse. Distinguishing between cholangiocarcinoma and IgG4\u2010sclerosing cholangitis is challenging, and a high clinical suspicion for cholangiocarcinoma must always be maintained. (<jats:italic toggle=\"yes\">Hepatology Communications<\/jats:italic> 2018;2:349\u2010353)<\/jats:p>","DOI":"10.1002\/hep4.1164","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T14:02:52Z","timestamp":1519826572000},"page":"349-353","source":"Crossref","is-referenced-by-count":6,"title":["Hilar cholangiocarcinoma associated with immunoglobulin G4\u2010positive plasma cells and elevated serum immunoglobulin G4 levels"],"prefix":"10.1097","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0846-6043","authenticated-orcid":false,"given":"Nabeel","family":"Azeem","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition,University of Minnesota,Minneapolis,MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veeral","family":"Ajmera","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology,University of California San Diego,San Diego,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-8428","authenticated-orcid":false,"given":"Bilal","family":"Hameed","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of California San Francisco,San Francisco,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9476-468X","authenticated-orcid":false,"given":"Neil","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of California San Francisco,San Francisco,CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"hep41164-bib-0001-20240502","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00535-016-1163-7","article-title":"IgG4\u2010related sclerosing cholangitis: all we need to know","volume":"51","year":"2016","journal-title":"J Gastroenterol"},{"key":"hep41164-bib-0002-20240502","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00534-012-0521-y","article-title":"Clinical diagnostic criteria of IgG4\u2010related sclerosing cholangitis 2012","volume":"19","year":"2012","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"hep41164-bib-0003-20240502","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jhep.2014.04.016","article-title":"IgG4 cholangiopathy: current concept, diagnosis, and pathogenesis","volume":"61","year":"2014","journal-title":"J Hepatol"},{"key":"hep41164-bib-0004-20240502","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/j.semdp.2012.08.001","article-title":"The pathology of IgG4\u2010related disease: critical issues and challenges","volume":"29","year":"2012","journal-title":"Semin Diagn Pathol"},{"key":"hep41164-bib-0005-20240502","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/j.gastro.2007.12.009","article-title":"Immunoglobulin G4\u2013associated cholangitis: clinical profile and response to therapy","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"hep41164-bib-0006-20240502","doi-asserted-by":"crossref","first-page":"e2052","DOI":"10.1097\/MD.0000000000002052","article-title":"Extensive metastatic cholangiocarcinoma associated with IgG4\u2010related sclerosing cholangitis misdiagnosed as isolated IgG4\u2010related sclerosing cholangitis: a case report and literature review","volume":"94","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"hep41164-bib-0007-20240502","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1053\/j.gastro.2015.10.015","article-title":"An unusual lesion presenting as cholangiopathy","volume":"150","year":"2016","journal-title":"Gastroenterology"},{"key":"hep41164-bib-0008-20240502","doi-asserted-by":"crossref","first-page":"e3785","DOI":"10.1097\/MD.0000000000003785","article-title":"Diagnostic value of serum IgG4 for IgG4\u2010related disease: a PRISMA\u2010compliant systematic review and meta\u2010analysis","volume":"95","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"hep41164-bib-0009-20240502","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/hep.24487","article-title":"Utility of serum immunoglobulin G4 in distinguishing immunoglobulin G4\u2010associated cholangitis from cholangiocarcinoma","volume":"54","year":"2011","journal-title":"Hepatology"},{"key":"hep41164-bib-0010-20240502","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.dld.2013.03.007","article-title":"Infiltration of peritumoural but tumour\u2010free parenchyma with IgG4\u2010positive plasma cells in hilar cholangiocarcinoma and pancreatic adenocarcinoma","volume":"45","year":"2013","journal-title":"Dig Liver Dis"},{"key":"hep41164-bib-0011-20240502","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/hep.25627","article-title":"Significance of immunoglobulin G4 (IgG4)\u2010positive cells in extrahepatic cholangiocarcinoma: molecular mechanism of IgG4 reaction in cancer tissue","volume":"56","year":"2012","journal-title":"Hepatology"},{"key":"hep41164-bib-0012-20240502","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3109\/00365521.2014.962603","article-title":"IgG4\u2010related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma","volume":"50","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"hep41164-bib-0013-20240502","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/MCG.0000000000000509","article-title":"Differential diagnosis of immunoglobulin G4\u2010associated cholangitis from cholangiocarcinoma","volume":"50","year":"2016","journal-title":"J Clin Gastroenterol"},{"key":"hep41164-bib-0014-20240502","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4251\/wjgo.v5.i8.181","article-title":"Cholangiocarcinoma developed in a patient with IgG4\u2010related disease","volume":"5","year":"2013","journal-title":"World J Gastrointest Oncol"},{"key":"hep41164-bib-0015-20240502","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2169\/internalmedicine.53.1342","article-title":"Incidence of malignancies in patients with IgG4\u2010related disease","volume":"53","year":"2014","journal-title":"Intern Med"},{"key":"hep41164-bib-0016-20240502","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/jnci\/djs351","article-title":"Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome","volume":"104","year":"2012","journal-title":"J Natl Cancer Inst"}],"container-title":["Hepatology Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep4.1164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep4.1164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep4.1164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/02009842-201804000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T10:00:55Z","timestamp":1714644055000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/02009842-201804000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1002\/hep4.1164","relation":{},"ISSN":["2471-254X","2471-254X"],"issn-type":[{"type":"print","value":"2471-254X"},{"type":"electronic","value":"2471-254X"}],"subject":[],"published":{"date-parts":[[2018,2,28]]}}}