{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:26:25Z","timestamp":1780719985777,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Communications"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Hepatoblastoma (HB) is the most common liver tumor in children. Despite recent improvements in treatment strategies, the survival of children with hepatoblastoma remains poor. In this study, we identified a novel role of microRNA\u201026a\u20105p (miR\u201026a\u20105p), lin\u201028 homolog B (LIN28B), Ras\u2010related nuclear protein (RAN), and aurora kinase A (AURKA) in HB. The expression of LIN28B, RAN, and AURKA was significantly up\u2010regulated in human HB livers and cell lines. Knockdown of LIN28B and RAN by small interfering RNAs inhibited HB tumor cell proliferation and foci formation. We also elucidated miR\u201026a\u20105p\u2010mediated translational inhibition of LIN28B and AURKA in HB. Overexpression of miR\u201026a\u20105p markedly decreased LIN28B and AURKA 3\u2032\u2010untranslated region activities and protein expression and repressed HB cell proliferation and colony formation. In contrast, re\u2010expression of LIN28B and AURKA rescued miR\u201026a\u20105p\u2010mediated suppression of HB cell growth and clonality. Importantly, a decreased miR\u201026a\u20105p expression correlated with the poor outcome of patients with HB.<jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>miR\u201026a\u20105p is a newly identified repressor of HB growth through its inhibition of the oncogenic LIN28B\u2013RAN\u2013AURKA pathway. (<jats:italic toggle=\"yes\">Hepatology Communications<\/jats:italic>2018;2:481\u2010491)<\/jats:p>","DOI":"10.1002\/hep4.1185","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T12:58:59Z","timestamp":1526907539000},"page":"861-871","source":"Crossref","is-referenced-by-count":20,"title":["MicroRNA\u201026\u20105p functions as a new inhibitor of hepatoblastoma by repressing lin\u201028 homolog B and aurora kinase a expression"],"prefix":"10.1097","volume":"2","author":[{"given":"Yutong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology and Neurobiology and Institute for Systems Genomics,University of Connecticut,Storrs,CT"},{"name":"Department of Pediatric Oncology,The First Hospital of Jilin University,Changchun,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology and Institute for Systems Genomics,University of Connecticut,Storrs,CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology and Institute for Systems Genomics,University of Connecticut,Storrs,CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthat","family":"Liangpunsakul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine,Indiana University School of Medicine,Indianapolis,IN"},{"name":"Department of Biochemistry and Molecular Biology,Indiana University School of Medicine,Indianapolis,IN"},{"name":"Roudebush Veterans Administration Medical Center,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hepatology,The First Hospital of Jilin 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