{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:50:37Z","timestamp":1789854637247,"version":"4.0.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Communications"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Obesity and steatosis have been associated with liver disease progression in patients with compensated advanced chronic liver disease (cACLD) (liver stiffness measurement [LSM] \u2265 10 kPa). The controlled attenuation parameter (CAP) estimates steatosis during LSM by transient elastography. We aimed to evaluate whether CAP is associated with the development of clinically relevant events in cACLD. Consecutive patients with cACLD and CAP measurements observed between September 2013 and September 2015 were retrospectively studied. Classical decompensation and severe bacterial infections on follow\u2010up were recorded. A predefined CAP cut\u2010off for steatosis was used (220 dB\/m; 90% sensitivity). The association among LSM, CAP, and events was assessed by univariate and multivariate Cox regression. Among the 193 patients (viral etiology = 58%; median Child score = 5; LSM = 15.1 kPa; CAP = 255 \u00b1 62 dB\/m) who were followed up in median for 18 months, 18 developed clinically relevant events (11 liver decompensation, 7 severe bacterial infections). Patients developing events had higher LSM (median: 30.8 versus 14.3 kPa, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) and showed trends for higher CAP (275 \u00b1 46 versus 252 \u00b1 63 dB\/m, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.07), lower platelet count (134 \u00b1 74 versus 167 \u00b1 74 G\/L, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.07), and worse liver function versus patients remaining compensated. Body mass index was similar in the two groups. All events were more frequent in patients with CAP being greater than or equal to 220 dB\/m (12.9% versus 1.6% in CAP &lt; 220; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.013), and 10 of 11 episodes of liver decompensation occurred in patients with CAP being greater than or equal to 220 dB\/m. Following multivariate analysis, LSM and CAP greater than or equal to 220 dB\/m remained independently associated with clinical events in the whole population and in patients with clinically significant portal hypertension. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> The CAP being greater than or equal to 220 dB\/m is associated with increased risk of clinical decompensation and bacterial infections independent of LSM in patients with cACLD and allows refining the noninvasive risk stratification in this population. (<jats:italic toggle=\"yes\">Hepatology Communications<\/jats:italic> 2018; 00:000\u2010000)<\/jats:p>","DOI":"10.1002\/hep4.1201","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:06:36Z","timestamp":1532477196000},"page":"933-944","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic Significance of Controlled Attenuation Parameter in Patients With Compensated Advanced Chronic Liver Disease"],"prefix":"10.1097","volume":"2","author":[{"given":"Cristina","family":"Margini","sequence":"first","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Murgia","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Stirnimann","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"De Gottardi","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Semmo","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Casu","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Dufour","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Swiss Liver Center, Hepatology,University Clinic for Visceral Surgery and Medicine, Inselspital, University of 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