{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:42:45Z","timestamp":1764996165763},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Communications"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)\/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV\/SOF when HCV\u2010RNA tested negative, suggesting a link between rapid HCV clearance and <jats:italic toggle=\"yes\">de novo<\/jats:italic> autoimmune diseases.<jats:italic toggle=\"yes\"> Conclusion:<\/jats:italic> This case report proposes new immunologic scenarios in patients with hepatitis C virus (HCV) with laboratory or clinical signs of autoimmunity during direct\u2010acting antiviral (DAA) therapy.<\/jats:p>","DOI":"10.1002\/hep4.1248","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T16:09:38Z","timestamp":1537891778000},"page":"1179-1183","source":"Crossref","is-referenced-by-count":12,"title":["Autoimmune Hepatitis During Ledipasvir\/Sofosbuvir Treatment of Hepatitis C: A Case Report"],"prefix":"10.1097","volume":"2","author":[{"given":"Giovanni","family":"Covini","sequence":"first","affiliation":[{"name":"Liver Unit and Center for Autoimmune Liver Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bredi","sequence":"additional","affiliation":[{"name":"Clinical Investigation Laboratory"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Badalamenti","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Roncalli","sequence":"additional","affiliation":[{"name":"Department of Pathology,Humanitas Clinical and Research Center,Rozzano,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Aghemo","sequence":"additional","affiliation":[{"name":"Liver Unit and Department of Biomedical Sciences,Humanitas University,Rozzano,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Colombo","sequence":"additional","affiliation":[{"name":"Liver Unit and Department of Biomedical Sciences,Humanitas University,Rozzano,Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"hep41248-bib-0001-20240114","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4254\/wjh.v6.i4.160","article-title":"Drug\u2010induced autoimmune liver disease: a diagnostic dilemma of an increasingly reported disease","volume":"6","year":"2014","journal-title":"World J Hepatol"},{"key":"hep41248-bib-0002-20240114","doi-asserted-by":"crossref","first-page":"11631","DOI":"10.18632\/oncotarget.24391","article-title":"Interferon\u2010free treatment for patients with chronic hepatitis C and autoimmune liver disease: higher SVR rates with special precautions for deterioration of autoimmune hepatitis","volume":"9","year":"2018","journal-title":"Oncotarget"},{"key":"hep41248-bib-0003-20240114","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","year":"1999","journal-title":"J Hepatol"},{"key":"hep41248-bib-0004-20240114","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","article-title":"Drug\u2010induced liver injury: recent advances in diagnosis and risk assessment","volume":"66","year":"2017","journal-title":"Gut"},{"key":"hep41248-bib-0005-20240114","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-0528.2002.017408.x","article-title":"Local control of the immune response in the liver","volume":"174","year":"2000","journal-title":"Immunol Rev"},{"key":"hep41248-bib-0006-20240114","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/01926230252824699","article-title":"Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity","volume":"30","year":"2002","journal-title":"Toxicol Pathol"},{"key":"hep41248-bib-0007-20240114","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1378\/chest.68.2.181","article-title":"Acetylation rates and monthly liver function tests during one year of isoniazid preventive therapy","volume":"68","year":"1975","journal-title":"Chest"},{"key":"hep41248-bib-0008-20240114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01926230590888306","article-title":"Idiosyncratic liver injury: challenges and approaches","volume":"33","year":"2005","journal-title":"Toxicol Pathol"},{"key":"hep41248-bib-0009-20240114","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ajg.2014.131","article-title":"Practice Parameters Committee of the American College of Gastroenterology. 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