{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:24:32Z","timestamp":1793971472347,"version":"4.8.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Bacterial infection is frequently observed in patients with alcoholic liver disease (ALD). We examined a possible role of <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic> in the development\/progression and severity of disease in patients with acute alcoholic hepatitis (AAH). Plasma specimens from 47 patients with AAH (16 moderate, Model for End\u2010Stage Liver Disease [MELD] score &lt;20]; 31 severe, MELD score &gt;20) and 22 healthy controls (HCs) were collected. Clinical, drinking history (lifetime drinking history [LTDH]), and demographic data were collected. Antibody tests for immunoglobulin (Ig) G, IgM, and IgA against two <jats:italic toggle=\"yes\">P. gingivalis <\/jats:italic>strains were performed. Between\u2010group comparisons and within\u2010group association analyses were carried out. Patients with severe AAH showed significantly higher plasma levels of IgG, IgA, and IgM against two <jats:italic toggle=\"yes\">P. gingivalis<\/jats:italic> strains (W83 and 33277) compared to HCs. Patients with moderate AAH also had significantly elevated anti\u2010<jats:italic toggle=\"yes\">P. gingivalis<\/jats:italic> IgA concentrations for both strains compared to HCs. Male patients with moderate AAH showed a significant inverse association in LTDH and anti\u2010<jats:italic toggle=\"yes\">P. gingivalis<\/jats:italic> IgM. The aspartate aminotransferase:alanine aminotransferase ratio was positively associated with IgM of both strains in male patients with moderate AAH. Female patients with severe AAH showed a significant association between MELD scores and W83 IgM. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Antibody response to <jats:italic toggle=\"yes\">P. gingivalis<\/jats:italic> in AAH is elevated. Significantly elevated plasma anti\u2010<jats:italic toggle=\"yes\">P. gingivalis<\/jats:italic> IgG, IgA, and IgM in severe AAH provide preliminary data that <jats:italic toggle=\"yes\">P. gingivalis<\/jats:italic> could be a novel risk factor in the development\/severity of AAH.<\/jats:p>","DOI":"10.1002\/hep4.1296","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T13:44:25Z","timestamp":1544795065000},"page":"293-304","source":"Crossref","is-referenced-by-count":22,"title":["Porphyromonas gingivalis as a Possible Risk Factor in the Development\/Severity of Acute Alcoholic Hepatitis"],"prefix":"10.1097","volume":"3","author":[{"given":"Yun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Medicine,University of Louisville,Louisville,KY"},{"name":"Alcohol Research Center,University of Louisville,Louisville,KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsalya","family":"Vatsalya","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of Louisville,Louisville,KY"},{"name":"Alcohol Research Center,University of Louisville,Louisville,KY"},{"name":"Hepatobiology and Toxicology Center,University of Louisville,Louisville,KY"},{"name":"Robley Rex VA Medical Center,Louisville,KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Gobejishvili","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of Louisville,Louisville,KY"},{"name":"Alcohol Research Center,University of Louisville,Louisville,KY"},{"name":"Hepatobiology and Toxicology Center,University of Louisville,Louisville,KY"},{"name":"Department of Pharmacology and Toxicology,University of Louisville,Louisville,KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Lamont","sequence":"additional","affiliation":[{"name":"Department of Oral Immunology and Infectious Diseases,University of Louisville,Louisville,KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of Louisville,Louisville,KY"},{"name":"Alcohol Research Center,University of Louisville,Louisville,KY"},{"name":"Hepatobiology and Toxicology Center,University of Louisville,Louisville,KY"},{"name":"Robley Rex VA Medical Center,Louisville,KY"},{"name":"Department of Pharmacology and Toxicology,University of Louisville,Louisville,KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of Louisville,Louisville,KY"},{"name":"Alcohol Research Center,University of Louisville,Louisville,KY"},{"name":"Hepatobiology and Toxicology 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