{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:36Z","timestamp":1792098576721,"version":"4.4.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T00:00:00Z","timestamp":1551484800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound\u2010detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross\u2010sectional study. In part 3, 5 patients with cirrhosis were entered in the <jats:italic toggle=\"yes\">in vivo<\/jats:italic> study and 4 healthy subjects (HSs) were entered in the <jats:italic toggle=\"yes\">in vitro<\/jats:italic> study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.012) and serum albumin (OR, \u22120.422; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40\u2010ligand (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0238), soluble Nox2\u2010derived peptide (sNox2\u2010dp; <jats:italic toggle=\"yes\">P <\/jats:italic>&lt; 0.0001), and urinary excretion of isoprostanes (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD40L (Spearman\u2019s rank correlation coefficient [<jats:italic toggle=\"yes\">rs\n                           <\/jats:italic>], \u22120.33; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), sNox2\u2010dp (<jats:italic toggle=\"yes\">rs\n                           <\/jats:italic>, \u22120.57; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001), and urinary excretion of isoprostanes (<jats:italic toggle=\"yes\">rs,<\/jats:italic> \u22120.48; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001) levels. The <jats:italic toggle=\"yes\">in vivo<\/jats:italic> study showed a progressive decrease in platelet aggregation, sNox2\u2010dp, and urinary 8\u2010iso prostaglandin F2\u03b1\u2010III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2\u2010dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. <jats:italic toggle=\"yes\">Conclusion: <\/jats:italic>Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation.<\/jats:p>","DOI":"10.1002\/hep4.1317","type":"journal-article","created":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T00:09:54Z","timestamp":1551571794000},"page":"504-512","source":"Crossref","is-referenced-by-count":70,"title":["Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis"],"prefix":"10.1097","volume":"3","author":[{"given":"Stefania","family":"Basili","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Biotechnologies,Sapienza University of Rome,Latina,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nocella","sequence":"additional","affiliation":[{"name":"IRCCS NeuroMed,Pozzilli,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bartimoccia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Raparelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine,Sapienza University of Rome,Rome,Italy"},{"name":"McGill University Health Center Research Institute, Center for Outcomes Research and Evaluation,Montreal,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Talerico","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Stefanini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio F.","family":"Romiti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perticone","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences,University of Catanzaro,Catanzaro,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino R.","family":"Corazza","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine,Fondazione IRCCS Policlinico San Matteo, University of Pavia,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Piscaglia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences,University of Bologna,Bologna,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Pietrangelo","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine 2, Department of Medical and Surgical Science for Children and Adults,University of Modena and Reggio Emilia,Modena,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Violi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PRO\u2010LIVER Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,3,2]]},"reference":[{"key":"hep41317-bib-0001-20240114","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1160\/TH16-10-0782","article-title":"Cirrhosis as a risk factor for venous thrombosis","volume":"117","year":"2017","journal-title":"Thromb Haemost"},{"key":"hep41317-bib-0002-20240114","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2004.01.001","article-title":"Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis","volume":"40","year":"2004","journal-title":"J Hepatol"},{"key":"hep41317-bib-0003-20240114","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11739-008-0128-0","article-title":"Portal vein thrombosis in liver 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