{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:53:25Z","timestamp":1777654405618,"version":"3.51.4"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Interleukin (IL)\u201033 was recently described as a new member of the IL\u20101 family; members of this family have proinflammatory activity. IL\u201033 and its soluble receptor ST2 (sST2) have been implicated in the pathogenesis of autoimmune diseases. This study investigated serum IL\u201033 and sST2 in type I autoimmune hepatitis (AIH) and the relationship of these molecules with clinical and pathologic parameters. Subjects included 65 patients with AIH who were diagnosed in our hospital. The control population included 17 healthy individuals and 36 patients with primary biliary cholangitis (PBC). Mean age at AIH diagnosis was 55.5\u00a0years, and the male\u2010to\u2010female ratio was 6:59. Serum IL\u201033 and sST2 levels were significantly higher in patients with AIH than in those with PBC or controls. Importantly, immunohistochemistry revealed high IL\u201033 expression in liver sections from patients with AIH. In particular, serum IL\u201033 and sST2 levels were significantly higher in acute\u2010onset AIH than in chronic\u2010onset AIH. Serum IL\u201033 levels were positively correlated with serum total bilirubin (TB), alanine aminotransferase (ALT), and necroinflammatory activity in AIH. We performed multivariate logistic regression analysis and found serum IL\u201033 levels to be independent factors for severe activity. Serum sST2 levels were positively correlated with serum TB and ALT and negatively correlated with serum albumin and prothrombin time in AIH. In particular, serum sST2 levels were significantly higher in severe symptoms of AIH. Serum IL\u201033 and sST2 levels in patients with AIH responsive to treatment with prednisolone were significantly decreased after treatment. Interestingly, serum IL\u201033 level was associated with a significantly increased risk of relapse. <jats:italic toggle=\"yes\">Conclusion: <\/jats:italic>IL\u201033\/ST2 may play an important role in the pathogenesis and severity of AIH and may be a promising target for AIH therapy.<\/jats:p>","DOI":"10.1002\/hep4.1326","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T05:44:57Z","timestamp":1551159897000},"page":"670-684","source":"Crossref","is-referenced-by-count":15,"title":["Interleukin\u201033\/ST2\u2010Mediated Inflammation Plays a Critical Role in the Pathogenesis and Severity of Type I Autoimmune Hepatitis"],"prefix":"10.1097","volume":"3","author":[{"given":"Kazumichi","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology,Fukushima Medical University School of Medicine,Fukushima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Fukushima Medical University School of Medicine,Fukushima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Fukushima Medical University School of Medicine,Fukushima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Fukushima Medical University School of Medicine,Fukushima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Okai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Fukushima Medical University School of Medicine,Fukushima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Pathology,Shirakawa Kousei General Hospital,Shirakawa,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Fukushima Medical University School of Medicine,Fukushima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"hep41326-bib-0001-20240114","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJM199604043341406","article-title":"Autoimmune hepatitis","volume":"334","year":"1996","journal-title":"N Engl J Med"},{"key":"hep41326-bib-0002-20240114","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-2007-979467","article-title":"The impact of autoimmunity on hepatocytes","volume":"27","year":"2007","journal-title":"Semin Liver Dis"},{"key":"hep41326-bib-0003-20240114","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2013.10.020","article-title":"Autoimmune hepatitis in Denmark: incidence, prevalence, prognosis, and causes of death. 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