{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:56:48Z","timestamp":1792634208614,"version":"4.5.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol. Commun."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>\n                    Elastographic measurement of liver stiffness is of growing importance in the assessment of liver disease. Pediatric experiences with this technique are primarily single center and limited in scope. The Childhood Liver Disease Research Network provided a unique opportunity to assess elastography in a well\u2010characterized multi\u2010institutional cohort. Children with biliary atresia (BA), alpha\u20101 antitrypsin deficiency (A1ATD), or Alagille syndrome (ALGS) followed in a prospective longitudinal network study were eligible for enrollment in a prospective investigation of transient elastography (FibroScan). Studies were performed in participants who were nonfasted and nonsedated. Liver stiffness measurements (LSMs) were correlated with standard clinical and biochemical parameters of liver disease along with a research definition of clinically evident portal hypertension (CEPH) graded as absent, possible, or definite. Between November 2016 and August 2019, 550 participants with a mean age of 8.8\u00a0years were enrolled, 458 of whom had valid LSMs (BA, n\u00a0=\u00a0254; A1ATD, n\u00a0=\u00a0104; ALGS, n\u00a0=\u00a0100). Invalid scans were more common in participants &lt;2\u00a0years old. There was a positive correlation between LSM and total bilirubin, international normalized ratio (INR), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma\u2010glutamyl transpeptidase (GGT), GGT to platelet ratio (GPR), pediatric end\u2010stage liver disease score, AST to platelet ratio index, and spleen size, and a negative correlation with albumin and platelet count in BA, with similar correlations for A1ATD (except AST, ALT, and albumin) and ALGS (except for INR, GGT, GPR, and ALT). Possible or definite CEPH was more common in BA compared to ALGS and A1ATD. LSM was greater in definite versus absent CEPH in all three diseases. Disease\u2010specific clinical and biochemical characteristics of the different CEPH grades were observed.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : It is feasible to obtain LSMs in children, especially over the age of 2\u00a0years. LSM correlates with liver parameters and portal hypertension, although disease\u2010specific patterns exist.\n                  <\/jats:p>","DOI":"10.1002\/hep4.1574","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T09:05:57Z","timestamp":1596618357000},"page":"1694-1707","source":"Crossref","is-referenced-by-count":30,"title":["Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease"],"prefix":"10.1097","volume":"4","author":[{"given":"Benjamin L.","family":"Shneider","sequence":"first","affiliation":[{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital,Houston,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health,Ann Arbor,MI,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ye","sequence":"additional","affiliation":[{"name":"University of Michigan,Ann Arbor,MI,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Sawyers","sequence":"additional","affiliation":[{"name":"Riley Hospital for Children,Indiana University,Indianapolis,IN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Molleston","sequence":"additional","affiliation":[{"name":"Riley Hospital for Children,Indiana University,Indianapolis,IN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Merion","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health,Ann Arbor,MI,USA"},{"name":"University of Michigan,Ann Arbor,MI,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital,Houston,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul J.","family":"Karpen","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta and Emory University School of Medicine,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binita M.","family":"Kamath","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children and the University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital,Houston,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Wang","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Los Angeles,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Teckman","sequence":"additional","affiliation":[{"name":"School of Medicine,Saint Louis University,St. Louis,MI,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Squires","sequence":"additional","affiliation":[{"name":"UPMC Children\u2019s Hospital of Pittsburgh,Pittsburgh,PA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha S.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine,Children\u2019s Hospital Colorado,Pittsburgh,PA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"University of California San Francisco,San Francisco,CA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Romero","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta and Emory University School of Medicine,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen F.","family":"Murray","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital and the University of Washington School of Medicine,Seattle,WA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Loomes","sequence":"additional","affiliation":[{"name":"The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania,Philadelphia,PA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kyle","family":"Jensen","sequence":"additional","affiliation":[{"name":"Primary Children\u2019s Hospital and University of Utah,Salt Lake City,UT,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-7742","authenticated-orcid":false,"given":"Jorge A.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center,Cincinnati,OH,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Bass","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital and Northwestern University,Chicago,IL,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Sokol","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine,Children\u2019s Hospital Colorado,Pittsburgh,PA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Magee","sequence":"additional","affiliation":[{"name":"University of Michigan,Ann Arbor,MI,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the Childhood Liver Disease Research Network (ChiLDReN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"hep41574-bib-0001-20240114","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/hepr.12815","article-title":"Liver fibrosis assessment by FibroScan compared with pathological findings of liver resection specimen in hepatitis C infection","volume":"47","year":"2017","journal-title":"Hepatol Res"},{"key":"hep41574-bib-0002-20240114","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/jum.14764","article-title":"Diagnostic performance of ultrasound elastography for evaluating portal hypertension in children: a systematic review and meta\u2010analysis","volume":"38","year":"2019","journal-title":"J Ultrasound Med"},{"key":"hep41574-bib-0003-20240114","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/MPG.0000000000001448","article-title":"Correlation of transient elastography with severity of cystic fibrosis\u2010related liver disease","volume":"64","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep41574-bib-0004-20240114","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-230X-11-41","article-title":"Transient elastography for predicting esophageal\/gastric varices in children with biliary atresia","volume":"11","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"hep41574-bib-0005-20240114","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.29905","article-title":"Biliary atresia: clinical and research challenges for the twenty\u2010first century","volume":"68","year":"2018","journal-title":"Hepatology"},{"key":"hep41574-bib-0006-20240114","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/liv.14035","article-title":"Liver disease related to alpha1\u2010antitrypsin deficiency in French children: the DEFI\u2010ALPHA cohort","volume":"39","year":"2019","journal-title":"Liver Int"},{"key":"hep41574-bib-0007-20240114","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/j.gastro.2019.05.013","article-title":"Liver fibrosis and metabolic alterations in adults with alpha\u20101\u2010antitrypsin deficiency caused by the Pi*ZZ mutation","volume":"157","year":"2019","journal-title":"Gastroenterology"},{"key":"hep41574-bib-0008-20240114","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cld.2018.06.001","article-title":"Alagille syndrome","volume":"22","year":"2018","journal-title":"Clin Liver Dis"},{"key":"hep41574-bib-0009-20240114","article-title":"Outcomes of childhood cholestasis in Alagille syndrome: results of a multicenter observational study","year":"2020","journal-title":"Hepatol Commun"},{"key":"hep41574-bib-0010-20240114","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/MPG.0000000000002333","article-title":"Clinically evident portal hypertension: an operational research definition for future investigations in the pediatric population","volume":"68","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep41574-bib-0011-20240114","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/jvh.12842","article-title":"Comparative evaluation of GPR versus APRI and FIB\u20104 in predicting different levels of liver fibrosis of chronic hepatitis B","volume":"25","year":"2018","journal-title":"J Viral Hepat"},{"key":"hep41574-bib-0012-20240114","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00431-011-1558-7","article-title":"Feasibility study and control values of transient elastography in healthy children","volume":"171","year":"2012","journal-title":"Eur J Pediatr"},{"key":"hep41574-bib-0013-20240114","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/MPG.0b013e31829206a0","article-title":"Application and limitations of transient liver elastography in children","volume":"57","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep41574-bib-0014-20240114","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12887-019-1487-6","article-title":"Feasibility study and reference values of FibroScan 502 with M probe in healthy preschool children aged 5 years","volume":"19","year":"2019","journal-title":"BMC Pediatr"},{"key":"hep41574-bib-0015-20240114","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/petr.12116","article-title":"The use of transient elastography and non\u2010invasive serum markers of fibrosis in pediatric liver transplant recipients","volume":"17","year":"2013","journal-title":"Pediatr Transplant"},{"key":"hep41574-bib-0016-20240114","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/jvh.13093","article-title":"Advanced liver disease in Russian children and adolescents with chronic hepatitis C","volume":"26","year":"2019","journal-title":"J Viral Hepat"},{"key":"hep41574-bib-0017-20240114","article-title":"Usefulness of transient elastography for non\u2010invasive diagnosis of liver fibrosis in pediatric non\u2010alcoholic steatohepatitis","volume":"34","year":"2019","journal-title":"J Korean Med Sci"},{"key":"hep41574-bib-0018-20240114","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/MPG.0000000000000489","article-title":"Points to be considered when applying FibroScan S probe in children with biliary atresia","volume":"59","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep41574-bib-0019-20240114","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jhep.2011.08.007","article-title":"Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard","volume":"56","year":"2012","journal-title":"J Hepatol"},{"key":"hep41574-bib-0020-20240114","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/MPG.0b013e31826eb0cf","article-title":"Portal hypertension in children and young adults with biliary atresia","volume":"55","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Hepatology Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep4.1574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep4.1574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep4.1574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep4.1574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T11:09:50Z","timestamp":1705230590000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep4.1574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,5]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1002\/hep4.1574","relation":{},"ISSN":["2471-254X","2471-254X"],"issn-type":[{"value":"2471-254X","type":"print"},{"value":"2471-254X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,5]]}}}