{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:23:17Z","timestamp":1769530997555,"version":"3.49.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Prognostic assessment of patients with liver cirrhosis allocated for implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a challenging task in clinical practice. The aim of our study was to assess the prognostic value of the CLIF\u2010C AD (Acute Decompensation) score in patients with TIPS implantation. Transplant\u2010free survival (TFS) and 3\u2010month mortality were reviewed in 880 patients who received <jats:italic toggle=\"yes\">de novo<\/jats:italic> TIPS implantation for the treatment of cirrhotic portal hypertension. The prognostic value of the CLIF\u2010C AD score was compared with the Model for End\u2010Stage Liver Disease (MELD) score, Child\u2010Pugh score, and albumin\u2010bilirubin (ALBI) score using Harrell\u2019s C concordance index. The median TFS after TIPS implantation was 40.0 (34.6\u201045.4) months. The CLIF\u2010C AD score (c\u00a0=\u00a00.635 [0.609\u20100.661]) was superior in the prediction of TFS in comparison to MELD score (c\u00a0=\u00a00.597 [0.570\u20100.623], <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.006), Child\u2010Pugh score (c\u00a0=\u00a00.579 [0.552\u20100.606], <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001), and ALBI score (c\u00a0=\u00a00.573 [0.545\u20100.600], <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). However, the CLIF\u2010C AD score did not perform significantly better than the MELD\u2010Na score (c\u00a0=\u00a00.626 [0.599\u20100.653], <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.442). There were no profound differences in the scores\u2019 ranking with respect to indication for TIPS implantation, stent type, or underlying liver disease. Subgroup analyses revealed that a CLIF\u2010C AD score &gt;45 was a predictor of 3\u2010month mortality in the supposed low\u2010risk group of patients with a MELD score \u226412 (14.7% vs. 5.1%, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> The CLIF\u2010C AD score is suitable for prognostic assessment of patients with cirrhotic portal hypertension receiving TIPS implantation. In the prediction of TFS, the CLIF\u2010C AD score is superior to MELD score, Child\u2010Pugh score, and ALBI score but not the MELD\u2010Na score.<\/jats:p>","DOI":"10.1002\/hep4.1654","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T08:23:49Z","timestamp":1609921429000},"page":"650-660","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic Value of the CLIF\u2010C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt"],"prefix":"10.1097","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3623-7857","authenticated-orcid":false,"given":"Lukas","family":"Sturm","sequence":"first","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"},{"name":"Berta\u2010Ottenstein\u2010Programme,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-9956","authenticated-orcid":false,"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[{"name":"Department of Medicine I,Medical Center University of Bonn,Faculty of Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-8729","authenticated-orcid":false,"given":"Dominik","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"},{"name":"Berta\u2010Ottenstein\u2010Programme,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Volkwein","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Kaeser","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine I,Medical Center University of Bonn,Faculty of Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Medicine I,Medical Center University of Bonn,Faculty of Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology,Medical Center University of Bonn,Faculty of Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Radiology,Medical Center University of Bonn,Faculty of Medicine,University of Bonn,Bonn,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty of Medicine,University of Freiburg,Freiburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3881","authenticated-orcid":false,"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Department of Medicine I,Medical Center University of Bonn,Faculty of Medicine,University of Bonn,Bonn,Germany"},{"name":"Department of Medicine I,Medical Center University of Frankfurt,Faculty of Medicine,University of Frankfurt,Frankfurt am Main,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schulthei\u00df","sequence":"additional","affiliation":[{"name":"Department of Medicine II,Medical Center University of Freiburg,Faculty 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