{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:32:14Z","timestamp":1780144334815,"version":"3.54.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Noninvasive monitoring of disease activity in autoimmune hepatitis (AIH) has potential advantages for patients for whom liver biopsy is invasive and with risk. We sought to understand the association of multiparametric magnetic resonance imaging (mpMRI) with clinical course of patients with AIH. We prospectively recruited 62 patients (median age, 55\u00a0years; 82% women) with clinically confirmed AIH. At recruitment, patients underwent mpMRI with Liver<jats:italic toggle=\"yes\">MultiScan<\/jats:italic> alongside clinical investigations, which were repeated after 12\u201018\u00a0months. Associations between iron\u2010corrected T1 (cT1) and other markers of disease were investigated at baseline and at follow\u2010up. Discriminative performance of cT1, liver stiffness, and enhanced liver fibrosis (ELF) to identify those who failed to maintain remission over follow\u2010up was investigated using the areas under the receiver operating characteristic curves (AUCs). Baseline cT1 correlated with alanine aminotransferase (Spearman\u2019s correlation coefficient [<jats:italic toggle=\"yes\">r<\/jats:italic>\n                           <jats:sub>S<\/jats:sub>]\u00a0=\u00a00.28, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.028), aspartate aminotransferase (<jats:italic toggle=\"yes\">r<\/jats:italic>\n                           <jats:sub>S<\/jats:sub>\u00a0=\u00a00.26, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.038), international normalized ratio (<jats:italic toggle=\"yes\">r<\/jats:italic>\n                           <jats:sub>S<\/jats:sub>\u00a0=\u00a00.35 <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.005), Model for End\u2010Stage Liver Disease (<jats:italic toggle=\"yes\">r<\/jats:italic>\n                           <jats:sub>S<\/jats:sub>\u00a0=\u00a00.32, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.020), ELF (<jats:italic toggle=\"yes\">r<\/jats:italic>\n                           <jats:sub>S<\/jats:sub>\u00a0=\u00a00.29, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.022), and liver stiffness <jats:italic toggle=\"yes\">r<\/jats:italic>\n                           <jats:sub>S<\/jats:sub>\u00a0=\u00a00.51, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). After excluding those not in remission at baseline (n\u00a0=\u00a012), 32% of the remainder failed to maintain remission during follow\u2010up. Failure to maintain remission was associated with significant increases in cT1 over follow\u2010up (AUC, 0.71; 95% confidence interval [CI], 0.52\u20100.90; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.035) but not with changes in liver stiffness (AUC, 0.68; 95% CI, 0.49\u20100.87; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.067) or ELF (AUC, 0.57; 95% CI, 0.37\u20100.78; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.502). cT1 measured at baseline was a significant predictor of future loss of biochemical remission (AUC, 0.68; 95% CI, 0.53\u20100.83; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.042); neither liver stiffness (AUC, 0.53; 95% CI, 0.34\u20100.71; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.749) nor ELF (AUC, 0.52; 95% CI, 0.33\u20100.70; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.843) were significant predictors of loss of biochemical remission. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Noninvasive mpMRI has potential to contribute to risk stratification in patients with AIH.<\/jats:p>","DOI":"10.1002\/hep4.1687","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T22:31:49Z","timestamp":1614119509000},"page":"1009-1020","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Multiparametric Magnetic Resonance Imaging, Autoimmune Hepatitis, and Prediction of Disease Activity"],"prefix":"10.1097","volume":"5","author":[{"given":"Katherine","family":"Arndtz","sequence":"first","affiliation":[{"name":"Centre for Liver and Gastrointestinal Research,National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Centre,Birmingham,United Kingdom"},{"name":"University Hospitals Birmingham National Health Service (NHS) Foundation Trust,Birmingham,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shumbayawonda","sequence":"additional","affiliation":[{"name":"Perspectum Ltd,Oxford,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hodson","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham National Health Service (NHS) Foundation Trust,Birmingham,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Eddowes","sequence":"additional","affiliation":[{"name":"Centre for Liver and Gastrointestinal Research,National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Centre,Birmingham,United Kingdom"},{"name":"NIHR Nottingham Biomedical Research Centre,Nottingham University Hospitals NHS Trust and University of Nottingham,Nottingham,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dennis","sequence":"additional","affiliation":[{"name":"Perspectum Ltd,Oxford,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Thomaides\u2010Brears","sequence":"additional","affiliation":[{"name":"Perspectum Ltd,Oxford,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Mouchti","sequence":"additional","affiliation":[{"name":"Perspectum Ltd,Oxford,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt D.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Perspectum Ltd,Oxford,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajarshi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Perspectum Ltd,Oxford,United 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History"}},{"value":"2021-01-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}