{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:07:39Z","timestamp":1790287659771,"version":"4.1.0"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Experts have forewarned about the coronavirus disease 2019 (COVID\u201019) pandemic environment fomenting the rising incidence of alcohol use disorder (AUD) and alcohol\u2010associated liver disease (ALD). We performed a cross\u2010sectional study of ALD at our liver transplantation (LT) center, located in the initial U.S. epicenter, New York City. Centered around the \u201cstay at home\u201d order date in New York state, March 22, 2020, we defined three time periods: \u201cpre\u2010COVID\u201d (January 1, 2020\u2010March 21, 2020), \u201cCOVID\u2010quarantine\u201d (March 22, 2020\u2010April 22, 2020), and \u201cdeclining\u2010COVID\u201d (April 23, 2020\u2010August 25, 2020). We found a 62% increase in interhospital patient transfers for ALD from pre\u2010COVID (20 of 93, 21%) to the declining\u2010COVID period (43 of 127, 34%). Our inpatient liver census with ALD also increased: 38% pre\u2010COVID, 45% COVID\u2010quarantine, and 49% declining\u2010COVID. Among 30 patients with severe alcoholic hepatitis (AH) not responding to medical therapy since March 22, 2020, 9 underwent early LT for AH (16% of the total number of early LT during our 8\u2010year program). Three of 9 early\u2010LT recipients reported specific COVID\u2010related stressors. All 25 previous LT recipients with established abstinence pre\u2010COVID maintained abstinence at follow\u2010up visits during the declining\u2010COVID period. Of the 6 recipients with sustained alcohol use within 6 months before March 22, 2020, half regained abstinence during the declining\u2010COVID period. Our findings help confirm the predictions of rising AUD and ALD as an immediate consequence of the COVID\u201019 pandemic. This aftershock particularly affected ethnically diverse patients with ALD with high inpatient mortality, reflecting the disproportionate impact of COVID\u201019 on underserved and minority populations. Alcohol relapse did not occur in long\u2010term early LT for AH recipients during the time of COVID\u201019. This lends further support to AH being a viable indication for LT, with recipients able to demonstrate ongoing resilience in the face of this unprecedented universal stressor.<\/jats:p>","DOI":"10.1002\/hep4.1706","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T08:26:51Z","timestamp":1614932811000},"page":"1151-1155","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":42,"title":["COVID\u201019 Aftershocks on Alcohol\u2010Associated Liver Disease: An Early Cross\u2010Sectional Report From the U.S. Epicenter"],"prefix":"10.1097","volume":"5","author":[{"given":"Stephanie M.","family":"Rutledge","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine,Icahn School of Medicine at Mount Sinai,New York,NY,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Schiano","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute, Division of Liver Diseases, Department of Medicine,Icahn School of Medicine at Mount Sinai,New York,NY,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Florman","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute, Division of Abdominal Transplantation, Department of Surgery,Icahn School of Medicine at Mount Sinai,New York,NY,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-8418","authenticated-orcid":false,"given":"Gene Y.","family":"Im","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute, Division of Liver Diseases, Department of Medicine,Icahn School of Medicine at Mount Sinai,New York,NY,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"hep41706-bib-0002-20241015","article-title":"Changes in adult alcohol use and consequences during the COVID\u201019 pandemic in the US","volume":"3","year":"2020","journal-title":"JAMA Network Open"},{"key":"hep41706-bib-0003-20241015","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1176\/appi.ajp.2020.20040417","article-title":"New challenges in addiction medicine: COVID\u201019 infection in patients with alcohol and substance use disorders\u2014the perfect storm","volume":"177","year":"2020","journal-title":"Am J Psychiatry"},{"key":"hep41706-bib-0004-20241015","first-page":"1102","article-title":"COVID\u201019 hangover: a rising tide of alcohol use disorder and alcohol\u2010associated liver disease","volume":"72","year":"2020","journal-title":"Hepatology"},{"key":"hep41706-bib-0005-20241015","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1053\/j.gastro.2016.02.042","article-title":"Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA Alcoholic Hepatitis Consortia","volume":"150","year":"2016","journal-title":"Gastroenterology"},{"key":"hep41706-bib-0006-20241015","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/ajt.13586","article-title":"Early liver transplantation for severe alcoholic hepatitis in the United States\u2014a single\u2010center experience","volume":"16","year":"2016","journal-title":"Am J Transplant"},{"key":"hep41706-bib-0007-20241015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/lt.25681","article-title":"Meeting report: the Dallas consensus conference on liver transplantation for alcohol associated 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