{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:19:28Z","timestamp":1773019168189,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Hepatocellular carcinoma (HCC) can <jats:italic toggle=\"yes\">de novo<\/jats:italic> develop in patients with chronic hepatitis C even after the achievement of sustained virologic response (SVR). We characterized <jats:italic toggle=\"yes\">de novo<\/jats:italic> HCC after SVR, comparing it with HCC that developed in patients during persistent hepatitis C virus (HCV) infection. Characteristics, survival rates, and recurrence rates after curative treatment in 178 patients who developed initial HCC after SVR diagnosed between 2014 and 2020 were compared with those of 127 patients with initial HCC that developed during persistent HCV infection diagnosed between 2011 and 2015; HCC was detected under surveillance in both groups. HCC was less advanced and liver function worsened less in patients with SVR than in patients with persistent HCV. The survival rate after diagnosis was significantly higher for patients with SVR than for patients with persistent HCV (1\u2010, 3\u2010, and 5\u2010year survival rates, 98.2%, 92.5%, and 86.8% versus 89.5%, 74.7%, and 60.8%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). By contrast, the recurrence rate after curative treatment was similar between groups (1\u2010, 3\u2010, and 5\u2010year recurrence rates, 11.6%, 54.6%, and 60.4% versus 24.0%, 46.7%, and 50.4%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.7484). Liver function improved between initial HCC diagnosis and recurrence in patients with SVR (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.0191), whereas it worsened in the control group (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001). In addition, patients with SVR could receive curative treatment for recurrence more frequently than patients with persistent HCV (80.4% versus 47.8%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.0008). <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Survival of patients with <jats:italic toggle=\"yes\">de novo<\/jats:italic> HCC after SVR was significantly higher than that of patients in whom HCC developed during persistent HCV infection, despite similar rates of recurrence after curative treatment. A higher prevalence of curative treatment for recurrent HCC and improved liver function contributed to this result.<\/jats:p>","DOI":"10.1002\/hep4.1716","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T13:58:04Z","timestamp":1620223084000},"page":"1290-1299","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Characteristics and Prognosis of De Novo Hepatocellular Carcinoma After Sustained Virologic Response"],"prefix":"10.1097","volume":"5","author":[{"given":"Hidenori","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology,Ogaki Municipal Hospital,Ogaki,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Gastroenterology Center,Ehime Prefectural Central Hospital,Matsuyama,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-1352","authenticated-orcid":false,"given":"Haruki","family":"Uojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Internal Medicine,Kitasato University School of Medicine,Sagamihara,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akito","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Gastroenterology Center,Yokohama City University Medical Center,Yokohama,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritomo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Department of Internal Medicine,Otakanomori Hospital,Kashiwa,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takaguchi","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Kagawa Prefectural Central Hospital,Takamatsu,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Department of Internal Medicine,Shinmatusdo Central General Hospital,Matsudo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Department of Internal Medicine,Nippon Medical School,Tokyo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Virology and Liver Unit,Graduate School of Medical Sciences,Nagoya City University,Nagoya,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Saiseikai Niigata 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Hospital,Sapporo,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeang","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology,Department of Internal Medicine,Nippon Medical School Chiba Hokuso Hospital,Inzai,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Ogaki Municipal Hospital,Ogaki,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Chuma","sequence":"additional","affiliation":[{"name":"Gastroenterology Center,Yokohama City University Medical Center,Yokohama,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Senoh","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Kagawa Prefectural Central 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