{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:13:25Z","timestamp":1790806405310,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Hepcidin is a liver\u2010derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation. Genetic hepcidin inactivation leads to hereditary hemochromatosis, a disease of iron overload. We used wild\u2010type and Hjv\u2010\/\u2010 mice, a model of hemochromatosis, to examine the expression of ferroportin and other proteins of iron metabolism in hepcidin target tissues. The animals were previously subjected to dietary iron manipulations. In Hjv\u2010\/\u2010 mice, hepcidin messenger RNA correlated significantly with hepatic iron load (r\u00a0=\u00a00.8211, <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001), but was substantially lower compared with wild\u2010type controls. Duodenal ferroportin and divalent metal transporter 1 (DMT1), as well as splenic and hepatic ferroportin, were overexpressed in these animals. A high\u2010iron diet (2% carbonyl iron) suppressed duodenal DMT1 levels in both wild\u2010type and Hjv\u2010\/\u2010 mice; however, it did not affect duodenal ferroportin expression in Hjv\u2010\/\u2010 mice, and only reduced it in wild\u2010type mice. In contrast, the high\u2010iron diet decreased splenic ferroportin exclusively in Hjv\u2010\/\u2010 mice, whereas it induced hepatic ferroportin exclusively in wild\u2010type mice. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Our data show that dietary iron differentially affects ferroportin expression in mouse tissues and are consistent with hepcidin\u2010dependent and hepcidin\u2010independent mechanisms for ferroportin regulation. In the Hjv\u2010\/\u2010 mouse model of hemochromatosis, duodenal ferroportin remains unresponsive to iron but DMT1 is appropriately iron\u2010regulated.<\/jats:p>","DOI":"10.1002\/hep4.1780","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T07:37:40Z","timestamp":1626421060000},"page":"2139-2150","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Tissue\u2010Specific Regulation of Ferroportin in Wild\u2010Type and Hjv\u2010\/\u2010 Mice Following Dietary Iron Manipulations"],"prefix":"10.1097","volume":"5","author":[{"given":"Angeliki","family":"Katsarou","sequence":"first","affiliation":[{"name":"Department of Medicine,Lady Davis Institute for Medical Research,Jewish General Hospital,McGill University,Montreal,QC,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Gkouvatsos","sequence":"additional","affiliation":[{"name":"Department of Medicine,Lady Davis Institute for Medical Research,Jewish General Hospital,McGill University,Montreal,QC,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Fillebeen","sequence":"additional","affiliation":[{"name":"Department of Medicine,Lady Davis Institute for Medical Research,Jewish General Hospital,McGill University,Montreal,QC,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0057","authenticated-orcid":false,"given":"Kostas","family":"Pantopoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine,Lady Davis Institute for Medical Research,Jewish General Hospital,McGill 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