{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:14:34Z","timestamp":1782864874251,"version":"3.54.5"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>The benefit of endoscopic retrograde cholangiopancreatography (ERCP) for the treatment of primary sclerosing cholangitis (PSC) remains controversial. To identify predictors of jaundice resolution after ERCP and whether resolution is associated with improved patient outcomes, we conducted a retrospective cohort study of 124 patients with jaundice and PSC. These patients underwent endoscopic biliary balloon dilation and\/or stent placement at an American tertiary center, with validation in a separate cohort of 102 patients from European centers. Jaundice resolved after ERCP in 52% of patients. Median follow\u2010up was 4.8\u00a0years. Independent predictors of jaundice resolution included older age (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.048; odds ratio [OR], 1.03 for every 1\u2010year increase), shorter duration of jaundice (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.059; OR, 0.59 for every 1\u2010year increase), lower Mayo Risk Score (MRS) (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.025; OR, 0.58 for every 1\u2010point increase), and extrahepatic location of the most advanced biliary stricture (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.011; OR, 3.13). A logistic regression model predicted jaundice resolution with area under the receiver operator characteristic curve of 0.67 (95% confidence interval, 0.5\u20100.79) in the validation set. Independent predictors of death or transplant during follow\u2010up included higher MRS at the time of ERCP (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.0001; hazard ratio [HR], 2.33 for every 1\u2010point increase), lower total serum bilirubin before ERCP (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.031; HR, 0.91 for every 1\u00a0mg\/dL increase), and persistence of jaundice after endoscopic therapy (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.003; HR, 2.30). <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Resolution of jaundice after endoscopic treatment of biliary strictures is associated with longer transplant\u2010free survival of patients with PSC. The likelihood of resolution is affected by demographic, hepatic, and biliary variables and can be predicted using noninvasive data. These findings may refine the use of ERCP in patients with jaundice with PSC.<\/jats:p>","DOI":"10.1002\/hep4.1813","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:31:27Z","timestamp":1630564287000},"page":"809-820","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Predictors of Jaundice Resolution and Survival After Endoscopic Treatment of Primary Sclerosing Cholangitis"],"prefix":"10.1097","volume":"6","author":[{"given":"John E.","family":"Eaton","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Haseeb","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rupp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV,University Hospital of Heidelberg,Heidelberg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo H.","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Sheila Sherlock Liver Centre,Royal Free Hospital and the University College London Institute of Liver and Digestive Health,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"van Munster","sequence":"additional","affiliation":[{"name":"Amsterdam Universitair Medische Centra,Amsterdam,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Voitl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV,University Hospital of Heidelberg,Heidelberg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Thorburn","sequence":"additional","affiliation":[{"name":"Sheila Sherlock Liver Centre,Royal Free Hospital and the University College London Institute of Liver and Digestive Health,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyriel Y.","family":"Ponsioen","sequence":"additional","affiliation":[{"name":"Amsterdam Universitair Medische Centra,Amsterdam,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity T.","family":"Enders","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret T.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barham K.","family":"Abu Dayyeh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd H.","family":"Baron","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Chandrasekhara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Gostout","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Storm","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Dierkhising","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics,Mayo Clinic,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo 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