{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:45:32Z","timestamp":1793699132415,"version":"4.5.1"},"reference-count":83,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>\n                    Transmembrane 6 superfamily member 2 (\n                    <jats:italic toggle=\"yes\">TM6SF2<\/jats:italic>\n                    ) is located on chromosome 19 (19p12) and encodes for a protein of undetermined function. Genetic studies have reported the association between a nonsynonymous variant in\n                    <jats:italic toggle=\"yes\">TM6SF2<\/jats:italic>\n                    (E167K, rs58542926) with hepatic triglyceride content and its impact on the cardiovascular system. Clinical and epidemiological studies have confirmed the role of\n                    <jats:italic toggle=\"yes\">TM6SF2<\/jats:italic>\n                    in the development of nonalcoholic fatty liver disease (NAFLD). Recently,\n                    <jats:italic toggle=\"yes\">TM6SF2<\/jats:italic>\n                    was also shown to play an important role in promoting hepatic fibrosis and hepatocellular cancer in mouse models. This review aims to capture the physiological role of\n                    <jats:italic toggle=\"yes\">TM6SF2<\/jats:italic>\n                    in the regulation of lipid metabolism and its involvement in cardiometabolic diseases.\n                  <\/jats:p>","DOI":"10.1002\/hep4.1822","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T21:54:31Z","timestamp":1631829271000},"page":"448-460","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":133,"title":["TM6SF2: A Novel Genetic Player in Nonalcoholic Fatty Liver and Cardiovascular Disease"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-7710","authenticated-orcid":false,"given":"Fei","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine,The Second Xiangya Hospital of Central South University,Changsha,China"},{"name":"Department of Molecular Genetics,University of Texas Southwestern Medical Center,Dallas,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-1399","authenticated-orcid":false,"given":"Federico","family":"Oldoni","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics,University of Texas Southwestern Medical Center,Dallas,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-3970","authenticated-orcid":false,"given":"Avash","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics,University of Texas Southwestern Medical Center,Dallas,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"hep41822-bib-0001-20241115","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old 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