{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:53Z","timestamp":1786977893129,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>\n                    Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies. Early detection permits interventions that would prevent progression to cirrhosis or later stages of the disease. Herein, we have conducted the first comprehensive time\u2010course study of lipids using novel state\u2010of\u2010the art lipidomics methods in plasma and liver in the early stages of a mouse model of AFLD, i.e., Lieber\u2010DeCarli diet model. In ethanol\u2010treated mice, changes in liver tissue included up\u2010regulation of triglycerides (TGs) and oxidized TGs and down\u2010regulation of phosphatidylcholine, lysophosphatidylcholine, and 20\u201022\u2010carbon\u2010containing lipid\u2010mediator precursors. An increase in oxidized TGs preceded histological signs of early AFLD, i.e., steatosis, with these changes observed in both the liver and plasma. The major lipid classes dysregulated by ethanol play important roles in hepatic inflammation, steatosis, and oxidative damage.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    Alcohol consumption alters the liver lipidome before overt histological markers of early AFLD. This introduces the exciting possibility that specific lipids may serve as earlier biomarkers of AFLD than those currently being used.\n                  <\/jats:p>","DOI":"10.1002\/hep4.1825","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T03:03:21Z","timestamp":1637636601000},"page":"513-525","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol\u2010Induced Liver Damage"],"prefix":"10.1097","volume":"6","author":[{"given":"Jeremy P.","family":"Koelmel","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences,Yale School of Public Health,New Haven,CT,USA"},{"name":"Department of Pathology, Immunology and Laboratory Medicine,University of Florida,Gainesville,FL,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan 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