{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:02:28Z","timestamp":1781784148169,"version":"3.54.5"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Low\u2010level alcohol consumption is associated with reduced cardiovascular disease (CVD) in the general population. It is unclear whether this association is seen in patients with nonalcoholic fatty liver disease (NAFLD) who have an increased risk of CVD. We examined the association between alcohol consumption and CVD\u2010related outcomes in subjects with NAFLD from a general population cohort. Subjects participating in the 1994\u20101995 Busselton Health survey underwent clinical and biochemical assessment. NAFLD was identified using the Fatty Liver Index of &gt;60, and alcohol consumption quantified using a validated questionnaire. CVD hospitalizations and death during the ensuing 20\u00a0years were ascertained using the Western Australian data linkage system. A total of 659 of 4,843 patients were diagnosed with NAFLD. The average standard drinks per week was 8.0 for men and 4.0 for women. Men consuming 8\u201021 drinks per week had a 38% (hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.43\u20100.90) lower risk of CVD hospitalization as compared with men consuming 1\u20107 drinks per week. With both men and women combined, consumption of 8\u201021 drinks per week was associated with a 32% (HR 0.68, 95% CI 0.49\u20100.93) reduction in CVD hospitalization in minimally adjusted and 29% (HR 0.71, 95% CI 0.51\u20100.99) in fully adjusted models. No protective association was observed with binge drinking. There was no association between alcohol consumption and CVD death. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Low to moderate alcohol consumption is associated with fewer CVD hospitalizations but not CVD death in subjects with NAFLD.<\/jats:p>","DOI":"10.1002\/hep4.1828","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T07:49:37Z","timestamp":1640072977000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Alcohol Consumption and Cardiovascular Outcomes in Patients With Nonalcoholic Fatty Liver Disease: A Population\u2010Based Cohort Study"],"prefix":"10.1097","volume":"6","author":[{"given":"Malik","family":"Janjua","sequence":"first","affiliation":[{"name":"Department of Hepatology,Sir Charles Gairdner Hospital,Nedlands,WA,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population and global Health,University of Western Australia,Nedlands,WA,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Divitini","sequence":"additional","affiliation":[{"name":"School of Population and global Health,University of Western Australia,Nedlands,WA,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"McQuillan","sequence":"additional","affiliation":[{"name":"Medical School,University of Western Australia,Nedlands,WA,Australia"},{"name":"Department of Cardiovascular Medicine,Sir Charles Gairdner Hospital,Nedlands,WA,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-3411","authenticated-orcid":false,"given":"John K.","family":"Olynyk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Fiona Stanley Hospital,Murdoch,WA,Australia"},{"name":"School of Medical and Health Sciences,Edith Cowan University,Joondalup,WA,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Jeffrey","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Sir Charles Gairdner Hospital,Nedlands,WA,Australia"},{"name":"Medical School,University of Western Australia,Nedlands,WA,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-7909","authenticated-orcid":false,"given":"Leon A.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Sir Charles Gairdner Hospital,Nedlands,WA,Australia"},{"name":"Medical School,University of Western 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