{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T21:00:42Z","timestamp":1771275642594,"version":"3.50.1"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>\n                    The value of noninvasive tools in the diagnosis of autoimmune hepatitis (AIH)\u2013related cirrhosis and the prediction of clinical outcomes is largely unknown. We sought to evaluate (1) the utility of liver stiffness measurement (LSM) in the diagnosis of cirrhosis and (2) the performance of the Sixth Baveno Consensus on Portal Hypertension (Baveno VI), expanded Baveno VI, and the ANTICIPATE models in predicting the absence of varices needing treatment (VNT). A multicenter cohort of 132 patients with AIH\u2010related cirrhosis was retrospectively analyzed. LSM and endoscopies performed at the time of cirrhosis diagnosis were recorded. Most of the patients were female (66%), with a median age of 54\u00a0years. Only 33%\u201049% of patients had a LSM above the cutoff points described for the diagnosis of AIH\u2010related cirrhosis (12.5, 14, and 16\u00a0kPa). Patients with portal hypertension (PHT) had significantly higher LSM than those without PHT (15.7 vs. 11.7\u00a0kPa;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.001), but 39%\u201052% of patients with PHT still had LSM below these limits. The time since AIH diagnosis negatively correlated with LSM, with longer time being significantly associated with a lower proportion of patients with LSM above these cutoffs. VNT was present in 12 endoscopies. The use of the Baveno VI, expanded Baveno VI criteria, and the ANTICIPATE model would have saved 46%\u201063% of endoscopies, but the latter underpredicted the risk of VNT.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    LSM cutoff points do not have a good discriminative capacity for the diagnosis of AIH\u2010related cirrhosis, especially long\u2010term after treatment initiation. Noninvasive tools are helpful to triage patients for endoscopy.\n                  <\/jats:p>","DOI":"10.1002\/hep4.1889","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T04:09:27Z","timestamp":1641442167000},"page":"1392-1402","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Noninvasive Prediction of Outcomes in Autoimmune Hepatitis\u2013Related Cirrhosis"],"prefix":"10.1097","volume":"6","author":[{"given":"Laura\u2010Patricia","family":"Llovet","sequence":"first","affiliation":[{"name":"Liver Unit,Hospital Cl\u00ednic Barcelona,IDIBAPS,CIBEREHD,University of Barcelona,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Gratac\u00f3s\u2010Gin\u00e8s","sequence":"additional","affiliation":[{"name":"Liver Unit,Hospital Cl\u00ednic Barcelona,IDIBAPS,CIBEREHD,University of Barcelona,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-3891","authenticated-orcid":false,"given":"Luis","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Hospital Universitario Ram\u00f3n y Cajal,Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria,CIBEREHD,Universidad de Alcal\u00e1,Madrid,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"G\u00f3mez\u2010Outomuro","sequence":"additional","affiliation":[{"name":"16474,Liver Unit,Division of Gastroenterology & Hepatology,Hospital Universitario Central de Asturias,Oviedo,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen A.","family":"Navascu\u00e9s","sequence":"additional","affiliation":[{"name":"16474,Liver Unit,Division of Gastroenterology & Hepatology,Hospital Universitario Central de Asturias,Oviedo,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-2052","authenticated-orcid":false,"given":"Mar","family":"Riveiro\u2010Barciela","sequence":"additional","affiliation":[{"name":"Liver Unit,Internal Medicine Department,Vall d\u2019Hebron Hospital,CIBEREHD,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Vinuesa","sequence":"additional","affiliation":[{"name":"16821,Department of Hepatology and Gastroenterology,Hospital Universitario de Burgos,Burgos,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"G\u00f3mez\u2010Camarero","sequence":"additional","affiliation":[{"name":"16821,Department of Hepatology and Gastroenterology,Hospital Universitario de Burgos,Burgos,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Garc\u00eda\u2010Retortillo","sequence":"additional","affiliation":[{"name":"Liver Section,Gastroenterology Department,Departament der Medicina,Hospital del Mar,Universistat Autonoma de Barcelona,IMIM,Barcelona,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"D\u00edaz\u2010Fontenla","sequence":"additional","affiliation":[{"name":"Liver Unit and Digestive Department,Hospital General Universitario Gregorio Mara\u00f1\u00f3n,CIBEREHD,Madrid,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Liver Unit and Digestive Department,Hospital General Universitario Gregorio Mara\u00f1\u00f3n,CIBEREHD,Madrid,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda\u2010Eliz","sequence":"additional","affiliation":[{"name":"Liver Transplantation Unit and Hepatology,Hospital Universitario La Fe,CIBEREHD,Valencia,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Horta","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit,Hospital Universitari Mutua Terrassa,Terrassa,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation,IMIBIC,CIBEREHD, Hospital Universitario Reina Sof\u00eda,C\u00f3rdoba,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Rodr\u00edguez\u2010Per\u00e1lvarez","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation,IMIBIC,CIBEREHD, Hospital Universitario Reina Sof\u00eda,C\u00f3rdoba,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrado","family":"Fern\u00e1ndez\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n,Madrid,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Albillos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Hospital Universitario Ram\u00f3n y Cajal,Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria,CIBEREHD,Universidad de Alcal\u00e1,Madrid,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"G\u2010Abraldes","sequence":"additional","affiliation":[{"name":"Liver Unit,Division of Gastroenterology,CEGIIR,University of 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