{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:12:58Z","timestamp":1783566778493,"version":"3.55.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Fibroblast growth factor 1 (FGF1) belongs to a family of growth factors involved in cellular growth and division. MicroRNA 16 (miR\u201016) is a regulator of gene expression, which is dysregulated during liver injury and insult. However, the role of FGF1 in the progression of biliary proliferation, senescence, fibrosis, inflammation, angiogenesis, and its potential interaction with miR\u201016, are unknown. <jats:italic toggle=\"yes\">In vivo<\/jats:italic> studies were performed in male bile duct\u2013ligated (BDL, 12\u2010week\u2010old) mice, multidrug resistance 2 knockout (Mdr2<jats:bold>\n                              \u2212\/\u2212)\n                           <\/jats:bold> mice (10\u2010week\u2010old), and their corresponding controls, treated with recombinant human FGF1 (rhFGF1), fibroblast growth factor receptor (FGFR) antagonist (AZD4547), or anti\u2010FGF1 monoclonal antibody (mAb). <jats:italic toggle=\"yes\">In vitro<\/jats:italic>, the human cholangiocyte cell line (H69) and human hepatic stellate cells (HSCs) were used to determine the expression of proliferation, fibrosis, angiogenesis, and inflammatory genes following rhFGF1 treatment. PSC patient and control livers were used to evaluate FGF1 and miR\u201016 expression. Intrahepatic bile duct mass (IBDM), along with hepatic fibrosis and inflammation, increased in BDL mice treated with rhFGF1, with a corresponding decrease in miR\u201016, while treatment with AZD4547 or anti\u2010FGF1 mAb decreased hepatic fibrosis, IBDM, and inflammation in BDL and Mdr2<jats:bold>\n                              \u2212\/\u2212\n                           <\/jats:bold> mice. <jats:italic toggle=\"yes\">In vitro,<\/jats:italic> H69 and HSCs treated with rhFGF1 had increased expression of proliferation, fibrosis, and inflammatory markers. PSC samples also showed increased FGF1 and FGFRs with corresponding decreases in miR\u201016 compared with healthy controls. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Our study demonstrates that suppression of FGF1 and miR\u201016 signaling decreases the presence of hepatic fibrosis, biliary proliferation, inflammation, senescence, and angiogenesis. Targeting the FGF1 and miR\u201016 axis may provide therapeutic options in treating cholangiopathies such as PSC.<\/jats:p>","DOI":"10.1002\/hep4.1909","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T17:26:24Z","timestamp":1646933184000},"page":"1574-1588","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2\u2212\/\u2212 Mouse Model of Primary Sclerosing Cholangitis"],"prefix":"10.1097","volume":"6","author":[{"given":"April","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"12332,Department of Medical Physiology,Texas A&M University College of Medicine,Bryan,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"12250,Division of Gastroenterology and Hepatology,Department of Medicine,Indiana 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