{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:52:51Z","timestamp":1791647571913,"version":"4.3.4"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>As the US population ages, more elderly patients may need liver transplantation. Our aim was to assess recent trends among elderly individuals requiring liver transplant in the United States. Scientific Registry of Transplant Recipients data (2002\u20132020) were used to select elderly (\u226565 years) liver transplant candidates and assess on\u2010list and posttransplant outcomes. During the study period, 31,209 liver transplant candidates \u226565 years were wait listed. Common etiologies included nonalcoholic steatohepatitis (NASH; 31%), hepatitis C (23%), and alcoholic liver disease (18%); 30% also had hepatocellular carcinoma (HCC). Over time, the proportion of patients \u226565 years among all adult liver transplant candidates increased from 9% (2002\u20132005) to 23% (2018\u20132020) (trend, <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0&lt;\u00a00.0001). The proportion of NASH among elderly candidates increased from 13% (2002\u20132005) to 39% (2018\u20132020). Of the elderly candidates, 54% eventually received transplants. In multivariate analysis, independent predictors of a higher chance of receiving a transplant for the elderly included more recent years of listing, male sex, higher Model for End\u2010Stage Liver Disease (MELD) score, and HCC (all <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0&lt;\u00a00.01). Posttransplant mortality in elderly transplant recipients was higher than in younger patients but continued to decrease over time. In multivariate analysis, independent predictors of higher posttransplant mortality for elderly transplant recipients were earlier years of transplantation, older age, male sex, higher MELD score, history of diabetes, retransplantation, and having HCC (all <jats:italic toggle=\"yes\">p<\/jats:italic>\u00a0&lt;\u00a00.01). The proportion of elderly patients in need of liver transplantation in the United States is sharply increasing. NASH is the most common indication for liver transplantation among the elderly. The outcomes of these patients have been improving in the past 2 decades.<\/jats:p>","DOI":"10.1002\/hep4.1915","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T09:14:47Z","timestamp":1646039687000},"page":"1506-1515","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":63,"title":["Nonalcoholic steatohepatitis is the most common indication for liver transplantation among the elderly: Data from the United States Scientific Registry of Transplant Recipients"],"prefix":"10.1097","volume":"6","author":[{"given":"Maria","family":"Stepanova","sequence":"first","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research,Inova Health System,Falls Church,Virginia,USA"},{"name":"Center for Outcomes Research in Liver Diseases,Washington,DC,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Kabbara","sequence":"additional","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research,Inova Health System,Falls Church,Virginia,USA"},{"name":"Center for Liver Disease,Department of Medicine,Inova Fairfax Medical Campus,Falls Church,Virginia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Mohess","sequence":"additional","affiliation":[{"name":"Division of Palliative Care and Geriatrics,Inova Health System,Falls Church,Virginia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Verma","sequence":"additional","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research,Inova Health System,Falls Church,Virginia,USA"},{"name":"Division of Palliative Care and Geriatrics,Inova Health System,Falls Church,Virginia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alva","family":"Roche\u2010Green","sequence":"additional","affiliation":[{"name":"Division of Palliative Care and Geriatrics,Inova Health System,Falls Church,Virginia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"AlQahtani","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research in Liver Diseases,Washington,DC,USA"},{"name":"Division of Gastroenterology and Hepatology,Johns Hopkins University Medical Center,Baltimore,Maryland,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus","family":"Ong","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research in Liver Diseases,Washington,DC,USA"},{"name":"College of Medicine,University of the Philippines,Manila,Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Burra","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research in Liver Diseases,Washington,DC,USA"},{"name":"Department of Gastroenterology,Padua University,Padua,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"additional","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research,Inova Health System,Falls Church,Virginia,USA"},{"name":"Center for Outcomes Research in Liver Diseases,Washington,DC,USA"},{"name":"Center for Liver Disease,Department of Medicine,Inova Fairfax Medical Campus,Falls Church,Virginia,USA"},{"name":"Inova Medicine,Inova Health System,Falls Church,Virginia,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"hep41915-bib-0001-20241115","first-page":"474","article-title":"Liver transplantation","volume":"26","year":"1967","journal-title":"Bull Soc Int Chir"},{"key":"hep41915-bib-0002-20241115","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00595-020-01996-7","article-title":"Liver transplantation in elderly patients: what do we know at the beginning of 2020?","volume":"50","year":"2020","journal-title":"Surg Today"},{"key":"hep41915-bib-0003-20241115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00007890-199101000-00046","article-title":"Liver transplantation in patients over sixty years of 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