{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:32:43Z","timestamp":1778499163983,"version":"3.51.4"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We previously demonstrated that Mac\u20102 binding protein (M2BP) is a useful biomarker for nonalcoholic fatty liver disease (NAFLD), particularly NAFLD fibrosis prediction. In the present study, we investigated the prognostic value of M2BP in patients with NAFLD. A total of 506 patients with biopsy\u2010confirmed NAFLD from 2002 to 2013 were enrolled in this study in Japan. Three hundred fifty\u2010three of these patients with NAFLD were available for follow\u2010up for more than 100 days and showed no liver\u2010related events at the time of entry. Liver\u2010related events were defined as hepatocellular carcinoma (HCC), decompensation, and gastroesophageal varices with variceal treatment. The mean follow\u2010up duration of all the subjects was 2716 \u00b1 1621 days (102\u20137483 days). Eighteen patients developed new liver\u2010related events (HCC, 8; decompensation, 11; varices, 8). Nine patients developed cardiovascular disease (CVD), and 24 patients developed new cancers in other organs. The median serum M2BP level was 1.603 \u03bcg\/mL, and we divided our cohort into two groups according to the serum M2BP level: M2BP low group (M2BP Low) and M2BP high group (M2BP Hi). The incidence of HCC was significantly higher in M2BP Hi (n\u00a0=\u00a08) than in M2BP Low (n\u00a0=\u00a00). The incidence of liver\u2010related events was significantly higher in M2BP Hi (n\u00a0=\u00a016) than in M2BP Low (n\u00a0=\u00a02). The incidences of death, CVD events, and cancer in other organs were not different between the groups. Interestingly, the incidence of colorectal cancer was significantly higher in M2BP Hi (n\u00a0=\u00a05) than in M2BP Low (n\u00a0=\u00a00). <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: M2BP is a useful biomarker to predict liver\u2010related events, particularly HCC. Additionally, M2BP is a potential predictive biomarker of colorectal cancer development.<\/jats:p>","DOI":"10.1002\/hep4.1934","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T06:05:56Z","timestamp":1651125956000},"page":"1527-1536","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Serum Mac\u20102 binding protein level predicts the development of liver\u2010related events and colorectal cancer in patients with NAFLD"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-902X","authenticated-orcid":false,"given":"Yoshihiro","family":"Kamada","sequence":"first","affiliation":[{"name":"Department of Advanced Metabolic Hepatology,Osaka University Graduate School of Medicine,Suita,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism,Hiroshima University, Hiroshima,Hiroshima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Munekage","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Department of Gastroenterology and Hepatology,Kochi Medical School,Nankoku,Kochi,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Osaka Municipal University Graduate School of Medicine,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Sawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Ikeda Municipal Hospital,Ikeda,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Otemae Hospital,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Innovative Medicine for Hepatobiliary & Pancreatology,Kagawa University,Kagawa,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Hyogo","sequence":"additional","affiliation":[{"name":"Hyogo Life Care Clinic Hiroshima,Hiroshima,Japan"},{"name":"Department of Gastroenterology and Hepatology,JA Hiroshima General Hospital,Hiroshima,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Sumida","sequence":"additional","affiliation":[{"name":"Division of Hepatology and Pancreatology,Department of Internal Medicine,Aichi Medical University,Nagakute,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry & Clinical Investigation,Osaka University Graduate School of Medicine,Suita,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Asuka","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry & Clinical Investigation,Osaka University Graduate School of Medicine,Suita,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunenori","family":"Ouchida","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry & Clinical Investigation,Osaka University Graduate School of Medicine,Suita,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Ikeda Municipal Hospital,Ikeda,Osaka,Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biochemistry & 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