{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:04:11Z","timestamp":1773788651138,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Different reports have shown the clinical and serologic response to the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) messenger RNA (mRNA) vaccines in preventing coronavirus disease 2019 (COVID\u201019) in the general population, but few studies have examined these responses in transplant recipients. We assessed the vaccine immunogenicity of two doses (100 \u03bcg) of the mRNA\u20101273 vaccine (Moderna) administered with a 28\u2010day interval in liver transplant recipients (LTRs) at follow\u2010up at the Marques de Valdecilla University Hospital. LTRs without a history of COVID\u201019 infection were tested for SARS\u2010CoV\u20102 immunoglobulin G (IgG) antibodies directed against the spike protein (S) a median of 43 days after receiving the second Moderna vaccine dose. Clinical data, including immunosuppressive regimen and routine laboratory data, were obtained from the medical record of each patient up to 3 months before the date of the first vaccination. Factors associated with serologic response were evaluated through logistic regression. In total, 129 LTRs who had anti\u2010S results were included. Most patients were men (n = 99; 76.7%) with a median age of 63 years (interquartile range, 56\u201368). Alcohol (43.4%) and chronic hepatitis C (18.6%) were the most frequent causes of liver transplantation. A positive anti\u2010S IgG response was observed in 113 LTRs (87.6%; 95% confidence interval [CI], 80.8\u201392.2). A strong inverse relationship between mycophenolate mofetil use and serologic response was found (odds ratio, 0.07; 95% CI, 0.02\u20130.26; <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.001). <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Most LTRs develop an immunological response to the Moderna SARS\u2010CoV\u20102 mRNA\u2010based vaccine. An immunosuppressive regimen that includes mycophenolate predicts a weak serologic response.<\/jats:p>","DOI":"10.1002\/hep4.1937","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T15:23:18Z","timestamp":1648480998000},"page":"1673-1679","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Antibody response to the messenger RNA\u20101273 vaccine (Moderna) in liver transplant recipients"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1363-864X","authenticated-orcid":false,"given":"Antonio","family":"Cuadrado","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"Clinical and Translational Digestive Research Group,University of Cantabria,Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL),Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-7405","authenticated-orcid":false,"given":"Mar\u00eda","family":"del Barrio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"Clinical and Translational Digestive Research Group,University of Cantabria,Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL),Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ignacio","family":"Fortea","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"Clinical and Translational Digestive Research Group,University of Cantabria,Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL),Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Amigo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"Clinical and Translational Digestive Research Group,University of Cantabria,Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL),Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"San Segundo","sequence":"additional","affiliation":[{"name":"Department of Immunology,Marqu\u00e9s de Valdecilla University Hospital,IDIVAL,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Paz","family":"Rodriguez\u2010Cundin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine,Marqu\u00e9s de Valdecilla University Hospital,Cantabria,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Henar","family":"Rebollo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine,Marqu\u00e9s de Valdecilla University Hospital,Cantabria,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Fernandez\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"IDIVAL,School of Medicine,University of Cantabria,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"IDIVAL,School of Medicine,University of Cantabria,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Achalandabaso","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"IDIVAL,School of Medicine,University of Cantabria,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Echeverri","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"IDIVAL,School of Medicine,University of Cantabria,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"IDIVAL,School of Medicine,University of Cantabria,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Rodr\u00edguez\u2010Sanjuan","sequence":"additional","affiliation":[{"name":"Department of General Surgery,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"IDIVAL,School of Medicine,University of Cantabria,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"L\u00f3pez\u2010Hoyos","sequence":"additional","affiliation":[{"name":"Department of Immunology,Marqu\u00e9s de Valdecilla University Hospital,IDIVAL,Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Crespo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"Clinical and Translational Digestive Research Group,University of Cantabria,Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL),Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"F\u00e1brega","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Marqu\u00e9s de Valdecilla University Hospital,Santander,Spain"},{"name":"Clinical and Translational Digestive Research Group,University of Cantabria,Instituto de investigaci\u00f3n sanitaria Valdecilla (IDIVAL),Santander,Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"hep41937-bib-0001-20241115","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID\u201019): a 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