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This study aimed to clarify the incidence, survival probability, and factors associated with malignancy, especially non\u2010HCC malignancies, in patients with chronic HCV infection after achieving SVR. In this retrospective study, records of 3580 patients with chronic HCV infection who achieved SVR following direct\u2010acting antiviral (DAA) treatment were analyzed. The cumulative post\u2010SVR incidence of non\u2010HCC malignancies was 0.9%, 3.1%, and 6.8% at 1, 3, and 5 years, respectively. The survival probability for patients with non\u2010HCC malignancies was 99.1%, 78.8%, and 60.2% at 1, 3, and 5 years, respectively, and the rate was significantly lower than that for patients with HCC. The Cox proportional hazards regression model identified Mac\u20102\u2010binding protein glycan isomer (M2BPGi) cutoff index (COI) \u2265 1.90 at baseline and \u2265 1.50 at 12 weeks following DAA treatment as significant and independent factors associated with the post\u2010SVR incidence of non\u2010HCC malignancies. Furthermore, patients with either M2BPGi COI \u2265 1.90 at baseline or M2BPGi COI \u2265 1.50 at SVR12 had a significantly higher risk of post\u2010SVR incidence of non\u2010HCC malignancies than of HCC. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> M2BPGi measurements at baseline and SVR12 may help predict the post\u2010SVR incidence of non\u2010HCC malignancies in patients with chronic HCV infection who achieved SVR following DAA treatment. Early identification of these patients is critical to prolong patient survival.<\/jats:p>","DOI":"10.1002\/hep4.1941","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T15:23:19Z","timestamp":1648480999000},"page":"1855-1869","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Mac\u20102\u2010binding protein glycan isomer predicts all malignancies after sustained virological response in chronic hepatitis C"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-8578","authenticated-orcid":false,"given":"Kazuhito","family":"Kawata","sequence":"first","affiliation":[{"name":"12793,Hepatology Division,Department of Internal Medicine II,Hamamatsu University School of 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