{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:40:54Z","timestamp":1791819654073,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Cachexia occurs in late stages of liver cirrhosis, and a low\u2010fat mass is potentially associated with poor outcome. This study compared different computed tomography (CT)\u2013derived fat parameters with respect to its prognostic impact on the development of complications and death before and after liver transplantation. Between 2001 and 2014, 612 patients with liver cirrhosis without hepatocellular carcinoma listed for liver transplantation met the inclusion criteria, including abdominal CT scan (\u00b1200 days to listing). A total of 109 patients without cirrhosis served as controls. The subcutaneous fat index (SCFI), the paraspinal muscle fat index, and the visceral fat index were assessed at L3\/L4 level and normalized to the height (cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>). Data were collected and analyzed retrospectively. Low SCFI was associated with a higher rate of ascites and increased C\u2010reactive protein levels (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.001). In addition, multivariate Cox regression analysis adjusting for sex, age, body mass index (BMI), and Model for End\u2010Stage Liver Disease showed that decreasing SCFI was also associated with an increased risk of cirrhosis\u2010related complications (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.003) and death on the transplant wait list (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.013). Increased paraspinal and visceral fat were not only positively correlated with creatinine levels (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.001), BMI, and metabolic comorbidities (all <jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.001) before transplantation, but also predictive for 1\u2010year mortality after transplantation. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> The distribution of body fat is a major determinant for complications and outcome in cirrhosis before and after liver transplantation.<\/jats:p>","DOI":"10.1002\/hep4.1946","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:49:05Z","timestamp":1649936945000},"page":"2198-2209","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Body fat composition determines outcomes before and after liver transplantation in patients with cirrhosis"],"prefix":"10.1097","volume":"6","author":[{"given":"Cornelius","family":"Engelmann","sequence":"first","affiliation":[{"name":"Division of Hepatology,Department of Medicine II,Leipzig University Medical Center,Leipzig,Germany"},{"name":"Liver Failure Group,Institute for Liver and Digestive Health,University College London,Royal Free Campus,London,UK"},{"name":"Department of Hepatology and Gastroenterology,Campus Virchow\u2010Klinikum,Charit\u00e9\u2013Universitaetsmedizin Berlin,Berlin,Germany"},{"name":"522475,Berlin Institute of Health,Berlin,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-847X","authenticated-orcid":false,"given":"Niklas F.","family":"Aehling","sequence":"additional","affiliation":[{"name":"Division of Hepatology,Department of Medicine II,Leipzig University Medical Center,Leipzig,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schob","sequence":"additional","affiliation":[{"name":"Department for Neuroradiology,University Hospital Leipzig,Leipzig,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Nonnenmacher","sequence":"additional","affiliation":[{"name":"Division of Hepatology,Department of Medicine II,Leipzig University Medical Center,Leipzig,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Handmann","sequence":"additional","affiliation":[{"name":"Division of Hepatology,Department of Medicine II,Leipzig University Medical Center,Leipzig,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Macnaughtan","sequence":"additional","affiliation":[{"name":"Liver Failure Group,Institute for Liver and Digestive Health,University College London,Royal Free 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