{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T15:25:52Z","timestamp":1771687552222,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Patients with pre\u2010existing liver diseases are considered to have an increased risk of morbidity and mortality from any type of infection, including viruses. The aim of this work was to explore the implications of metabolic dysfunction\u2010associated fatty liver disease (MAFLD) and nonalcoholic fatty liver disease (NAFLD) definitions in coronavirus disease 2019 (COVID\u201019) and to study the interaction between advanced fibrosis (AF) and each of these diseases in the death and intubation of patients hospitalized with COVID\u201019. We performed a retrospective study with 359 patients hospitalized with confirmed COVID\u201019 infection in a tertiary referral hospital who were admitted between April and June 2020. A multivariate Cox model was performed regarding the interaction of AF with MAFLD and NAFLD in the mortality and intubation of patients with COVID\u201019. The death rate was statistically significantly higher in the MAFLD group compared to the control group (55% vs. 38.3%, <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.02). No significant difference was seen in the death rate between the NAFLD and control group. The MAFLD (44.09% vs. 20%, <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.001) and NAFLD (40.51% vs. 20%, <jats:italic toggle=\"yes\">p<\/jats:italic> = 0.01) groups had statistically significantly higher intubation rates than the control group. A statistically significant interaction between NAFLD and AF was associated with an increase in mortality (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.01), while a statistically significant interaction between MAFLD and AF was associated with an increased risk of mortality (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.006) and intubation (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.049). In the case of patients hospitalized with COVID\u201019, our results indicate that the death rate was higher in the MAFLD group but not the NAFLD group compared to that in the control group. The intubation rates were higher in the NAFLD and MAFLD groups compared to rates in the control group, suggesting that both could be associated with COVID\u201019 severity. In addition, we found interactions between AF with MAFLD and NAFLD.<\/jats:p>","DOI":"10.1002\/hep4.1957","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T10:16:47Z","timestamp":1650363407000},"page":"2000-2010","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Interaction of metabolic dysfunction\u2010associated fatty liver disease and nonalcoholic fatty liver disease with advanced fibrosis in the death and intubation of patients hospitalized with coronavirus disease 2019"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-7235","authenticated-orcid":false,"given":"Mart\u00edn Uriel","family":"V\u00e1zquez\u2010Medina","sequence":"first","affiliation":[{"name":"Becario de la Direcci\u00f3n General de Calidad y Educaci\u00f3n en Salud, Secretar\u00eda de Salud,Mexico City,Mexico"},{"name":"Escuela Superior de Medicina,Instituto Polit\u00e9cnico Nacional,Mexico City,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-888X","authenticated-orcid":false,"given":"Eira","family":"Cerda\u2010Reyes","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n Acad\u00e9mica,Hospital Central Militar,Secretaria de la Defensa Nacional,Mexico City,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Galeana\u2010Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Becario de la Direcci\u00f3n General de Calidad y Educaci\u00f3n en Salud, Secretar\u00eda de Salud,Mexico City,Mexico"},{"name":"Escuela Superior de Medicina,Instituto Polit\u00e9cnico Nacional,Mexico City,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Enrique","family":"L\u00f3pez\u2010Luna","sequence":"additional","affiliation":[{"name":"Becario de la Direcci\u00f3n General de Calidad y Educaci\u00f3n en Salud, Secretar\u00eda de Salud,Mexico City,Mexico"},{"name":"Escuela Superior de Medicina,Instituto Polit\u00e9cnico Nacional,Mexico City,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patty Marlen","family":"Ram\u00edrez\u2010Portillo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina,Benem\u00e9rita Universidad Aut\u00f3noma de Puebla,Puebla,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-0942","authenticated-orcid":false,"given":"Gabriela","family":"Iba\u00f1ez\u2010Cervantes","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina,Instituto Polit\u00e9cnico Nacional,Mexico City,Mexico"},{"name":"Divisi\u00f3n de Investigaci\u00f3n,Hospital Ju\u00e1rez de M\u00e9xico,Mexico City,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-2084","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Torres\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n Acad\u00e9mica,Hospital Central Militar,Secretaria de la Defensa Nacional,Mexico City,Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-3619","authenticated-orcid":false,"given":"Cruz","family":"Vargas\u2010De\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina,Instituto Polit\u00e9cnico Nacional,Mexico City,Mexico"},{"name":"Divisi\u00f3n de Investigaci\u00f3n,Hospital Ju\u00e1rez de M\u00e9xico,Mexico 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