{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:55:01Z","timestamp":1777589701496,"version":"3.51.4"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Studies have examined nonalcoholic fatty liver disease (NAFLD) prevalence and severity in Asians; however, this is not well understood in Asian Americans (both East and South Asian Americans) as few studies have analyzed this population. We aimed to describe characteristics, prevalence of NAFLD, and its severity in Asian Americans in the National Health and Nutrition Examination Surveys (NHANES) from 2017 to 2018. Respondents 18\u2009years and older with interview, laboratory testing, and transient elastography data were included. Other causes of liver disease were excluded. Controlled attenuation parameter (CAP) cutoff\u2009\u2265\u2009274\u2009dB\/m, as published in the literature, defined NAFLD. Sensitivity analysis for CAP cutoffs\u2009\u2265\u2009248 and \u2265302\u2009dB\/m were performed. We found that 450 out of 3639 respondents were Asian Americans, and prevalence using CAP\u2009\u2265\u2009274\u2009dB\/m was 43.23%. Using sensitivity analysis cutoffs of CAP\u2009\u2265\u2009248\u2009dB\/m and CAP\u2009\u2265\u2009302\u2009dB\/m, the prevalence was 57.38% and 28.03%, respectively. Compared with non\u2010Asian Americans with NAFLD, Asian Americans with NAFLD had significantly lower body mass index (BMI) and less prevalent smoking history. Comorbidities, such as prediabetes, diabetes, and hypertension, were not significantly different between Asian and non\u2010Asian Americans with NAFLD. Compared to non\u2010Asian Americans with NAFLD, Asian Americans with NAFLD exhibited higher aminotransferases and triglycerides. Fibrosis assessed by transient elastography was not significantly different between Asian and non\u2010Asian Americans with NAFLD. Despite decreased prevalence of BMI\u2009\u2265\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>, Asian Americans experienced similar NAFLD prevalence with increased hepatocellular injury and triglyceridemia compared to non\u2010Asian Americans. Fibrosis stages were similar to non\u2010Asian Americans.<\/jats:p>","DOI":"10.1002\/hep4.1981","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T07:29:36Z","timestamp":1652081376000},"page":"2253-2261","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Nonalcoholic fatty liver disease prevalence and severity in Asian Americans from the national health and nutrition examination surveys 2017\u20132018"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-3299","authenticated-orcid":false,"given":"Emily","family":"Truong","sequence":"first","affiliation":[{"name":"Department of Medicine,Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"},{"name":"Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Hui","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Medicine,Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"},{"name":"Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galen","family":"Cook\u2010Wiens","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Muthiah","sequence":"additional","affiliation":[{"name":"National University of Singapore,Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7834-9825","authenticated-orcid":false,"given":"Ju Dong","family":"Yang","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology,Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"},{"name":"Comprehensive Transplant Center,Cedars Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-7756","authenticated-orcid":false,"given":"Vinay","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology,Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"},{"name":"Comprehensive Transplant Center,Cedars Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devon","family":"Chang","sequence":"additional","affiliation":[{"name":"Arnold O. Beckman High School,Irvine,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Todo","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center,Cedars Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center,Cedars Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly C.","family":"Lu","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology,Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica Wendy","family":"Setiawan","sequence":"additional","affiliation":[{"name":"USC Research Center for Liver Diseases,University of Southern California School of Medicine,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-9410","authenticated-orcid":false,"given":"Vincent W. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong,Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine,University of Oxford,Oxford,UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naim","family":"Alkhouri","sequence":"additional","affiliation":[{"name":"Arizona Liver Health,Phoenix,Arizona,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Noureddin","sequence":"additional","affiliation":[{"name":"Karsh Division of Gastroenterology and Hepatology,Cedars\u2010Sinai Medical Center,Los Angeles,California,USA"},{"name":"Comprehensive Transplant Center,Cedars Sinai Medical Center,Los 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syndrome","volume":"28","year":"2014","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"hep41981-bib-0004-20241118","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0038-1677517","article-title":"NASH in lean individuals","volume":"39","year":"2019","journal-title":"Semin Liver Dis"},{"key":"hep41981-bib-0005-20241118","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.cgh.2020.06.066","article-title":"Lean Americans with nonalcoholic fatty liver disease have lower rates of cirrhosis and comorbid diseases","volume":"19","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"hep41981-bib-0006-20241118","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S2468-1253(19)30039-1","article-title":"Prevalence, incidence, and outcome of non\u2010alcoholic fatty liver disease in Asia, 1999\u20132019: a systematic review and meta\u2010analysis","volume":"4","year":"2019","journal-title":"Lancet Gastroenterol 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