{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:05:13Z","timestamp":1792001113967,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spleen stiffness measurement (SSM) by vibration\u2010controlled transient elastography (VCTE) is a noninvasive technique for estimating portal hypertension in patients with chronic liver disease (CLD), with its reproducibility yet to be established and its feasibility still unknown beyond CLD. We have studied 420 participants from two tertiary referral centers for liver diseases (Novara, Milan): 297 patients with CLD (32% with cirrhosis) of different etiology (Group A), 63 Philadelphia\u2010negative myeloproliferative neoplasms (Group B), and 60 heathy volunteers (Group C). All underwent SSM by VCTE with a spleen\u2010dedicated module (SSM@100\u2009Hz) and liver stiffness measurement (LSM), blindly performed by 2 different operators. In total, 1680 VCTE examinations for SSM were performed (1000 in Novara, 680 in Milan), with an overall 3.2% failure rate. Median SSM was 26.5\u00a0kPa (interquartile range [IQR] 20.0\u201342.3) in Group A, 26.3\u00a0kPa (IQR 22.3\u201333.6) in Group B, and 16.1\u00a0kPa (IQR 14.6\u201318.7) in Group C. In Group A, the median LSM was 6.8\u00a0kPa (IQR 4.9\u201311.3) in Novara and 8.3\u00a0kPa (IQR 7.1\u201310.8) in Milan, the proportion of patients with cirrhosis being 34% in Novara and 31% in Milan. The Group A interobserver agreement ICC was 0.90 (0.88\u20130.92), significantly lower in the absence of splenomegaly (ICC 0.87 vs. 0.91) and in absence of cirrhosis (ICC 0.84 vs. 0.90); overweight slightly, but not significantly reduced the interobserveragreement. The intra\u2010observer agreement ICC ranged from 0.91 to 0.96 for the four operators. The Group B interobserver agreement ICC was 0.90 (0.83\u20130.94). In conclusion, SSM measured by the new spleen\u2010dedicated VCTE module is a feasible, reliable, and highly reproducible tool in patients with CLD and hematological disorders, and in healthy volunteers.<\/jats:p>","DOI":"10.1002\/hep4.2070","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T16:36:36Z","timestamp":1662741396000},"page":"3006-3014","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["High reproducibility of spleen stiffness measurement by vibration\u2010controlled transient elastography with a spleen\u2010dedicated module"],"prefix":"10.1097","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2089-4139","authenticated-orcid":false,"given":"Cristina","family":"Rigamonti","sequence":"first","affiliation":[{"name":"Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micol Giulia","family":"Cittone","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Francesca","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sorge","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit,Fondazione IRCCS Ca' Granda\u2013Ospedale Maggiore Policlinico,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Moia","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Azienda Ospedaliero\u2013Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Patriarca","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Azienda Ospedaliero\u2013Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Donato","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit,Fondazione IRCCS Ca' Granda\u2013Ospedale Maggiore Policlinico,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Azienda Ospedaliero\u2013Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Pirisi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine,Universit\u00e0 del Piemonte Orientale and Division of Internal Medicine, Azienda Ospedaliero\u2010Universitaria Maggiore della Carit\u00e0,Novara,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Fraquelli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit,Fondazione IRCCS Ca' Granda\u2013Ospedale Maggiore 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