{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:56:43Z","timestamp":1761631003873,"version":"3.40.5"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatol Commun"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Few studies have reported on acoustic radiation force impulse (ARFI) for varices screening. Our study aimed to identify a strategy based on liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) by ARFI combined with platelet count (PLT), named the ARP strategy, for ruling out high\u2010risk varices (HRV) and avoiding unnecessary esophagogastroduodenoscopy (EGD) in patients with compensated cirrhosis. We retrospectively reviewed patients who underwent ARFI from a previous cohort (NCT04307264). Of them, patients between 2017 and 2019 composed the training cohort to develop the ARP strategy. The validation cohort consisted of others between 2015 and 2016 to validate and compare it with Baveno VI criteria about the performance for varices screening. Primary outcomes were the rates of spared EGDs and HRV missed. A total of 741 consecutive patients were included in the final analysis. Of them, 576 patients were included in the training cohort and 165 patients in the validation cohort. In the training cohort, ARP strategy was defined as LSM\u2009&lt;\u20091.805\u2009m\/s or SSM\u2009&lt;\u20092.445\u2009m\/s and PLT\u2009&gt;\u2009110\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. ARP strategy could spare 234 (40.6%) EGDs with a missed HRV rate of 3.4% (8 of 234). In the validation cohort, compared with Baveno VI criteria, the ARP strategy improved the proportion of avoided EGDs (49.7% vs. 34.5%; <jats:italic toggle=\"yes\">p<\/jats:italic>\u2009&lt;\u20090.001) and lowered the rate of misclassified HRV (1.2% vs. 3.5%; <jats:italic toggle=\"yes\">p<\/jats:italic>\u2009&lt;\u20090.001). <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: The ARP strategy was an efficient and safe tool for varices screening in compensated cirrhosis, and it might be an auxiliary or even alternative to Baveno VI criteria.<\/jats:p>","DOI":"10.1002\/hep4.2076","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T15:55:08Z","timestamp":1663602908000},"page":"3154-3162","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["A strategy for varices screening based on acoustic radiation force impulse combined with platelet (CHESS2001): An alternative of Baveno VI criteria"],"prefix":"10.1097","volume":"6","author":[{"given":"Yifei","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Tianjin Second People's Hospital,Tianjin,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiling","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Portal Hypertension,The First Hospital of Lanzhou University,Lanzhou,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Tianjin Second People's Hospital,Tianjin,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School,Southeast University,Nanjing,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-5855","authenticated-orcid":false,"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Portal Hypertension,The First Hospital of Lanzhou University,Lanzhou,China"},{"name":"Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School,Southeast University,Nanjing,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-417X","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Tianjin Second People's 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